{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:51:27Z","timestamp":1791881487002,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the impact of hemoglobin (HGB) levels on therapeutic efficacy and energy dosage during ultrasound\u2010guided high\u2010intensity focused ultrasound (USgHIFU) ablation of symptomatic uterine fibroids (UFs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1196 patients who underwent USgHIFU for symptomatic UFs were retrospectively enrolled. Patients were stratified into 8 subgroups based on preprocedural HGB concentrations (g\/L): &lt;60, 60\u201370, 70\u201380, 80\u201390, 90\u2013100, 100\u2013110, 110\u2013120, and &gt;120. The energy efficiency factor (EEF) was used to quantify the ablation dose, and non\u2010perfused volume ratio (NPVR) was adopted to evaluate ablation efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall median EEF was 3.96\u2009J\/mm\n                      <jats:sup>3<\/jats:sup>\n                      . EEF was significantly lower in the &lt;60 (3.63\u2009J\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ) and 60\u201370\u2009g\/L (4.75\u2009J\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ) groups than in the 80\u201390\u2009g\/L group (6.62\u2009J\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ), and the 80\u201390\u2009g\/L group had higher EEF than the &gt;120\u2009g\/L group. The proportion of T2\u2010weighted imaging hyperintense fibroids (Funaki type 3) and NPVR was both higher in the 80\u201390\u2009g\/L group than in the &gt;120\u2009g\/L group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lower preprocedural HGB levels correlate with higher NPVR. During moderate anemia, EEF increases with rising HGB, which may serve as useful reference evidence for individualized energy dose adjustment in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70326","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T09:28:16Z","timestamp":1781602096000},"page":"2443-2451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Hemoglobin Levels on Therapeutic Efficacy and Energy Dosage in Ultrasound\u2010Guided\n                    <scp>HIFU<\/scp>\n                    Ablation of Uterine Fibroids"],"prefix":"10.1002","volume":"45","author":[{"given":"Meijie","family":"Yang","sequence":"first","affiliation":[{"name":"College of Artificial Intelligence Medicine, State Key Laboratory of Ultrasound in Medicine Chongqing Medical University  Chongqing 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