{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:51:20Z","timestamp":1791881480819,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Osteoarthritis pain is a common chronic pain. Low intensity pulsed ultrasound (LIPUS) is a non\u2010invasive treatment commonly used for musculoskeletal system diseases, but it is unclear whether it can alleviate osteoarthritis (OA) pain. The aim of this study is to investigate the therapeutic effects of LIPUS on pain relief and joint repair in OA rat models, and to explore its potential mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010four Sprague\u2013Dawley rats were divided into Sham, monosodium iodoacetate (MIA), MIA\u2009+\u2009LIPUS, and MIA\u2009+\u2009Sham LIPUS groups. OA was induced via intra\u2010articular MIA injection. LIPUS was administered for 20\u2009minutes\/14\u2009days. Behavioral tests, quantitative real\u2010time reverse transcription polymerase chain reaction (qRT\u2010PCR), histopathological, and immunohistochemical assessments were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LIPUS significantly increased paw withdrawal thresholds (PWT) and thermal withdrawal latencies (PWL), improved gait symmetry, and enhanced total walking distance.\n                      <jats:italic>Piezo1<\/jats:italic>\n                      ,\n                      <jats:italic>Piezo2<\/jats:italic>\n                      ,\n                      <jats:italic>Trpv1<\/jats:italic>\n                      , and\n                      <jats:italic>Calca<\/jats:italic>\n                      (encoding CGRP) mRNA levels in dorsal root ganglia were downregulated. Histopathological and immunohistochemical analysis revealed that LIPUS treatment preserved cartilage matrix integrity, reduced cartilage surface erosion, decreased Mankin scores, and promoted cartilage regeneration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LIPUS significantly alleviated OA\u2010induced pain and joint damage in rats by downregulating mRNA expression of pain\u2010related molecules and promoting cartilage preservation. These findings suggested that LIPUS has the potential to be a non\u2010invasive, non\u2010pharmacological therapy for OA, offering a promising alternative to conventional treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70339","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:12:13Z","timestamp":1781752333000},"page":"2475-2486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low Intensity Pulsed Ultrasound Alleviates the Pain of Monosodium Iodoacetate\u2010Induced Osteoarthritis in Rats"],"prefix":"10.1002","volume":"45","author":[{"given":"Zhihua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital)  Qingdao City 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