{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:51:22Z","timestamp":1791881482281,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010804","name":"Faculty of Medicine, Prince of Songkla University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To establish gestational age\u2010specific reference ranges for the intraplacental vascular index measured using microvascularity\u2010flow ultrasound software (VI\n                      <jats:sup>MV<\/jats:sup>\n                      ) and to evaluate its variation by placental location, parity, and pregnancy outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective study enrolled 354 singleton pregnancies, of which 243 (68.64%) uncomplicated cases were used to construct reference ranges. A residual bootstrap method with 500 iterations was applied to square\u2010root\u2013transformed VI\n                      <jats:sup>MV<\/jats:sup>\n                      values, followed by back\u2010transformation to derive the 5th, 50th, and 95th percentiles with 95% confidence intervals. Group differences were assessed using quantile regression, and associations with Doppler parameters were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      VI\n                      <jats:sup>MV<\/jats:sup>\n                      increased significantly with advancing gestational age (linear coefficient 1.88,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.007), following a curvilinear pattern with mild late\u2010gestation downturn (quadratic coefficient\u2009\u2212\u20090.036,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.011). Posterior placentas showed slightly higher early values, although this difference was not significant; from 31\u2009weeks onward, anterior placentas demonstrated significantly higher VI\n                      <jats:sup>MV<\/jats:sup>\n                      (mean difference\u2009+\u200915.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.010 at 31\u201335\u2009weeks; +11.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003 at 36\u201340\u2009weeks). Multiparous women showed a modestly higher fitted trajectory and a similar non\u2010significant trend toward higher birthweight, but parity was not independently associated with VI\n                      <jats:sup>MV<\/jats:sup>\n                      . Pregnancies complicated by maternal disease, hypertensive disorders, or small\u2010for\u2010gestational\u2010age neonates exhibited lower trajectories than uncomplicated pregnancies, although these differences were not statistically significant. VI\n                      <jats:sup>MV<\/jats:sup>\n                      was inversely associated with uterine and umbilical artery pulsatility indices and positively associated with umbilical vein time\u2010averaged mean velocity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Gestational age\u2013specific VI\n                      <jats:sup>MV<\/jats:sup>\n                      reference ranges were established. VI\n                      <jats:sup>MV<\/jats:sup>\n                      may provide an adjunctive quantitative marker for assessing placental vascular adaptation and identifying pregnancies with altered placental perfusion.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70344","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:30:49Z","timestamp":1782538249000},"page":"2499-2511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Placental Assessment Using Microvascular Flow Imaging: Reference Ranges and Clinical Application"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4441-4988","authenticated-orcid":false,"given":"Manaphat","family":"Suksai","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1219-9814","authenticated-orcid":false,"given":"Alan","family":"Geater","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thitima","family":"Suntharasaj","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-2359","authenticated-orcid":false,"given":"Chitkasaem","family":"Suwanrath","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninlapa","family":"Pruksanusak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natthicha","family":"Chainarong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Prince of Songkla University  Songkhla 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