{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:51:29Z","timestamp":1791881489327,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Ultrasound\u2010guided radiofrequency ablation (RFA) is an effective alternative to surgery for benign thyroid nodules (BTNs). This study aimed to evaluate the 2\u2010year clinical outcomes of RFA, focusing on volume reduction rate across different baseline volume strata.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single\u2010center prospective study included 200 patients with 213 BTNs treated with RFA. Nodules were stratified into 3 groups based on baseline volume: Group A (&lt;5\u2009mL,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200991), Group B (5\u201315\u2009mL,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200995), and Group C (&gt;15\u2009mL,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927). Clinical outcomes were assessed at 6, 12, 18, and 24\u2009months. The primary metrics were the volume reduction rate (VRR), therapeutic success (VRR &gt;50%), and complication rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      RFA resulted in continuous and significant volume reduction. Median VRR increased from 66.06% at 6\u2009months to 97.08% at 24\u2009months. Distinct reduction patterns were observed: at 6\u2009months, larger nodules (Group C) exhibited a higher VRR (85.40%) than Group A (59.51%) and Group B (64.33%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001). However, disparities narrowed over time. By 24\u2009months, all groups achieved comparable outcomes (VRR: 97.67, 95.22, and 98.53%, respectively). Therapeutic success ranged from 92.3 to 100%. Regrowth occurred in 2.8% of cases. The complication rate was 2.5% with no major events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RFA demonstrates favorable long\u2010term efficacy. Larger nodules shrink faster initially, while smaller nodules reduce gradually but eventually achieve comparable success. Patients with smaller nodules should be counseled to expect a more gradual volume reduction process.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70346","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T10:04:54Z","timestamp":1781949894000},"page":"2521-2530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound\u2010Guided Radiofrequency Ablation of Benign Thyroid Nodules: 2\u2010Year Follow\u2010Up Results From a Single Center"],"prefix":"10.1002","volume":"45","author":[{"given":"Jimei","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital of Traditional Chinese Medicine The Tenth Clinical Medical College of Guangzhou University of Traditional Chinese Medicine  Guangdong 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University of Traditional Chinese Medicine  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital of Traditional Chinese Medicine The Tenth Clinical Medical College of Guangzhou University of Traditional Chinese Medicine  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital of Traditional Chinese Medicine The Tenth Clinical Medical College of Guangzhou University of Traditional Chinese Medicine  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital of Traditional Chinese Medicine The Tenth Clinical Medical College of Guangzhou University of Traditional Chinese 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