{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:19:12Z","timestamp":1791307152824,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"abstract":"\n Objectives<\/jats:title>\n To evaluate the usefulness of transperineal ultrasonography (TPUS) for assessing the activity of perianal fistulas by exploring features associated with the magnetic resonance novel index for fistula imaging in Crohn's disease (MAGNIFI\u2010CD).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This single\u2010center retrospective study included pediatric patients (age <19\u2009years) who were admitted for an initial evaluation for known or suspected Crohn's disease (CD) and underwent both pelvic MRI and TPUS between September 2021 and October 2023. Patients without perianal fistula or with an interval between pelvic MRI and TPUS >1\u2009week were excluded. Following US features were evaluated: location, longitudinal length of the fistula, extension, diameter perpendicular to longitudinal axis, branching, vascularity, abscess, dominant feature, and proctitis. Multivariable linear regression analysis was performed to identify US features associated with MAGNIFI\u2010CD score. Changes in TPUS features were compared between responder and non\u2010responder groups.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 44 patients were included (median age [interquartile range], 14 [13\u201316] years, boys:girls, 36:8). Multivariable linear regression analysis showed that fistula length (regression coefficient [standard error], 1.48 [0.48];\n p<\/jats:italic>\n \u2009=\u2009.004) and vascularity (regression coefficient [standard error], 2.87 [1.00];\n p<\/jats:italic>\n \u2009=\u2009.007) on TPUS were associated with MAGNIFI\u2010CD score. In 25 patients with clinical follow\u2010up data, the extent of change in vascularity was significantly higher in the clinical responder group (change in vascularity treated as an ordinal variable, 0.94\u2009\u00b1\u20090.77 versus 0.11\u2009\u00b1\u20090.78;\n p<\/jats:italic>\n \u2009=\u2009.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n TPUS, especially through measurement of fistula length and vascularity, is a feasible adjunct to pelvic MRI for evaluating the severity and monitoring the treatment response of perianal fistulas in pediatric patients with CD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jum.70425","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T02:43:28Z","timestamp":1787193808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasound Features Associated with Activity of Perianal Fistulas in Pediatric Patients with Crohn's Disease"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6134-0724","authenticated-orcid":false,"given":"Ok Jeong","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, ASAN Medical Center Children's Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Mang","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, ASAN Medical Center Children's Hospital Seoul Republic of Korea"},{"name":"Department of Radiology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-6240","authenticated-orcid":false,"given":"Ah Young","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, ASAN Medical Center Children's Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ah","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, ASAN Medical Center Children's Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8470-4595","authenticated-orcid":false,"given":"Jin Seong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, ASAN Medical Center Children's Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9672-8877","authenticated-orcid":false,"given":"Seak Hee","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Ulsan College of Medicine, ASAN Medical Center Children's Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery University of Ulsan College of Medicine, ASAN Medical Center Children's Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Man","family":"Namgoong","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery University of Ulsan College of Medicine, ASAN Medical Center Children's Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunhee","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery University of Ulsan College of Medicine, ASAN Medical Center Children's Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7896-6751","authenticated-orcid":false,"given":"Kyung Mo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Ulsan College of Medicine, ASAN Medical Center Children's Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4276-8803","authenticated-orcid":false,"given":"Pyeong Hwa","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, ASAN Medical Center Children's Hospital Seoul Republic 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