{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:42:00Z","timestamp":1789393320893,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Chronic venous insufficiency (CVI) of the lower extremities negatively affects quality of life due to pain and cosmetic concerns. According to the muscle pump theory, lower extremity muscles contribute significantly to venous return; however, data regarding the relationship between muscle thickness, elasticity, and venous reflux are limited. This prospective study aimed to evaluate the association between lower extremity muscle reserve and elasticity with venous reflux and to investigate the usefulness of shear wave elastography (SWE) in monitoring treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between August 2024 and January 2025, 25 consecutive patients with clinically diagnosed CVI were prospectively enrolled in this study. Clinical examination and Clinical\u2013Etiological\u2013Anatomical\u2013Pathophysiological classification were performed in all individuals. Rectus femoris and gastrocnemius muscle thickness were measured by ultrasonography, and elasticity was assessed using SWE. Venous reflux parameters were evaluated with color Doppler ultrasonography. Following baseline assessment, all patients completed a structured physical therapy program. Clinical and radiological evaluations were repeated after treatment; then pre\u2010 and post\u2010therapy findings were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010six extremities of 25 patients (11 bilateral) were included in this study. Post\u2010treatment measurements demonstrated significant increases in rectus femoris and gastrocnemius muscle thickness and SWE values (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u2009.03) and a significant decrease in femoral and popliteal vein reflux times (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01) compared to baseline values. Changes in rectus femoris SWE values showed a weak negative correlation with femoral vein reflux time (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01). Increased gastrocnemius thickness was weakly and inversely correlated with popliteal vein reflux time (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Muscle thickness and elasticity assessed by ultrasonography and SWE are associated with reflux duration in CVI and may serve as useful adjunctive parameters for evaluating response to physical therapy. Larger studies are needed to confirm their clinical applicability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70428","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:48:50Z","timestamp":1787546930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Muscle Mass and Ultrasound Elastography Values in Patients with Lower Extremity Venous Insufficiency"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0821-3632","authenticated-orcid":false,"given":"Mustafa","family":"Sa\u011fan","sequence":"first","affiliation":[{"name":"Department of Radiology Yalva\u00e7 State Hospital  Isparta Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-8243","authenticated-orcid":false,"given":"\u0130lker","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery University of Health Sciences Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3064-2878","authenticated-orcid":false,"given":"Meral","family":"Bilgilisoy Filiz","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation University of Health Sciences Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7787-399X","authenticated-orcid":false,"given":"Nazmi","family":"Ka\u015ftan","sequence":"additional","affiliation":[{"name":"Department of Radiology D\u00f6\u015femealt\u0131 State Hospital  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-8341","authenticated-orcid":false,"given":"\u0130clal","family":"Erdem Toslak","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Health Sciences Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319701052001S02"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/1677-5449.190054"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006898"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2007.007061"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526\/a000635"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2005.07.019"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-921961"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/016173469101300201"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14904"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ruq.0b013e31815b7ed6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10090385"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2015.03.007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X241311254"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2019.11.027"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319703054001S02"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153239"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/1677-5449.200125"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.25270\/owm.2017.08.3043"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbmt.2022.09.026"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573405617666210507122819"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbmt.2023.04.068"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.136.12.1364"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.70428","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:49:01Z","timestamp":1787546941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.70428"}},"subtitle":["A Qualitative and Quantitative Analysis and Comparison of Their Potential Effects on Reflux Severity"],"short-title":[],"issued":{"date-parts":[[2026,8,23]]},"references-count":22,"alternative-id":["10.1002\/jum.70428"],"URL":"https:\/\/doi.org\/10.1002\/jum.70428","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,23]]},"assertion":[{"value":"2026-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jum.70428"}}