{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:07:47Z","timestamp":1789117667789,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of ultrasound (US)\u2010guided pulsed radiofrequency (PRF) on the lumbar sympathetic ganglion (LSG) for treating painful diabetic neuropathy (PDN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 228 patients were retrospectively included. Patients undergoing PRF under US guidance were identified as US cohort. A 1:1 propensity\u2010score matching was performed to select controls that received FL\u2010guided procedures. Primary endpoint was the proportion of patients experiencing at least a 50% reduction in pain at 1\u2009week after treatment. Noninferiority margin was set as 10%. Secondary outcomes included procedure outcomes, lower limb temperature, and scores of numerical rating scale (NRS) pain, neuropathy impairment score\u2010lower limbs (NIS\u2010LL), medical outcomes study sleep scale (MOS\u2010SS), hospital anxiety and depression scale (HADS), and Norfolk quality of life\u2010diabetic neuropathy (Norfolk QoL\u2010DN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In US cohort, 67.8% of patients reported \u226550% pain relief at 1\u2009week, with a mean difference of \u22120.9% (95% CI: \u22129.5%, 7.8%) between the 2 cohorts, exceeding the non\u2010inferiority margin. The proportion of patients achieving \u226550% pain relief remained at 65.6% in US cohort versus 66.7% in FL cohort at 4\u2009weeks post\u2010treatment, and 63.3% in US cohort versus 64.0% in FL cohort at 12\u2009weeks post\u2010treatment, with no significant inter\u2010cohort differences at all follow\u2010up time points. Temperature was immediately increased by 5\u00b0C in both cohorts. Significant improvements were observed in NRS pain, NIS\u2010LSS, MOS\u2010SS, HADS, and Norfolk QoL\u2010DN scores across the entire 12\u2010week follow\u2010up, with no significant differences between the cohorts (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05). US cohort was associated with fewer number of needle insertions, shorter performance times, less radiation dosages, and a lower incidence of intravascular puncture (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>US\u2010guided PRF on the LSG was shown to be non\u2010inferior to procedures under conventional FL guidance for treating PDN. Its unique advantages supported its application in clinical settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70442","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:27:58Z","timestamp":1789115278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound\u2010Guided Neuromodulation Is Non\u2010inferior to Fluoroscopy Approach for Painful Diabetic Neuropathy"],"prefix":"10.1002","author":[{"given":"Ling","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology Chinese People's Armed Police Force Hospital of Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Qin","sequence":"additional","affiliation":[{"name":"Outpatient Department Chinese People's Armed Police Force Hospital of Beijing  Beijing 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Analysis"],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":27,"alternative-id":["10.1002\/jum.70442"],"URL":"https:\/\/doi.org\/10.1002\/jum.70442","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"assertion":[{"value":"2026-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jum.70442"}}