{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:14:38Z","timestamp":1792181678947,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JEADV Clinical Practice"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic urticaria (CU) is characterised by recurring itchy hives lasting more than 6 weeks, with or without angioedema. Although CU patients are known to have an increased likelihood of psychiatric comorbidities, research exploring this connection in diverse populations remains limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study investigates the association between CU and psychiatric disorders using the All of Us (AoU) database, a nationwide initiative designed to enhance research in underrepresented populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a nested case\u2010control study among US adults in the AoU program from May 6, 2018 to February 26, 2025. SNOMED codes were used to identify CU cases that were then matched 4:1 to controls by age, sex, ethnicity, and smoking status. Psychiatric comorbidities were assessed using logistic regression models adjusted for hypothyroidism, systemic lupus erythematosus, and rheumatoid arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 1171 CU cases and 4684 matched controls. CU was significantly associated with increased odds of ADHD (odds ratio [OR], 3.61; 95% confidence interval [CI], 2.62\u20134.96), anxiety (OR, 3.48; 95% CI, 3.03\u20133.99), depression (OR, 3.26; 95% CI, 2.84\u20133.75), dysthymia (OR, 3.67; 95% CI, 2.89\u20134.66), insomnia (OR, 3.27; 95% CI, 2.77\u20133.86), psychological stress (OR, 3.92; 95% CI, 3.09\u20134.96), PTSD (OR, 3.25; 95% CI, 2.53\u20134.17), and substance use disorder (OR, 2.13; 95% CI, 1.74\u20132.62).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings highlight the psychiatric burden associated with CU and demonstrates the importance of routine psychiatric screenings for CU patients to allow early intervention. Prospective studies investigating additional psychiatric disorders and underlying mechanisms will help clarify meaningful associations and guide appropriate psychiatric screening and management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jvc2.70063","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:45:17Z","timestamp":1747208717000},"page":"836-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Psychiatric Comorbidities With Chronic Urticaria: A Nested Case\u2010Control Study in the All of Us Research Program"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2929-0207","authenticated-orcid":false,"given":"Nana A.","family":"Adjei\u2010Frimpong","sequence":"first","affiliation":[{"name":"Department of Dermatology University of California San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Cortes","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savannah K.","family":"Fakhouri","sequence":"additional","affiliation":[{"name":"San Diego, School of Medicine University of California San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Delacqua","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Research Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18240"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1809937"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.0190"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01761-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.043"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae239"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23539"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.170060"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-6730-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720002299"}],"container-title":["JEADV Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jvc2.70063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T14:20:40Z","timestamp":1756736440000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jvc2.70063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/jvc2.70063"],"URL":"https:\/\/doi.org\/10.1002\/jvc2.70063","archive":["Portico"],"relation":{},"ISSN":["2768-6566","2768-6566"],"issn-type":[{"value":"2768-6566","type":"print"},{"value":"2768-6566","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"assertion":[{"value":"2025-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}