{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:40:08Z","timestamp":1789429208677,"version":"build-2803163510"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JEADV Clinical Practice"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterized by the rapid onset of painful ulcers. Previous retrospective population\u2010based studies have identified a relationship between PG and major adverse cardiovascular events (MACE). However, these studies lacked appropriate control groups and were not conducted in the United States (US).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study examines the association between PG and MACE using the All of Us (AoU) database, a nationwide initiative created to increase research in underrepresented populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a nested case\u2010control study among US adults in the AoU programme from 6 May 2018 to 2 March 2025. SNOMED codes were used to identify all conditions. PG cases were then matched 4:1 to controls by age, sex, ethnicity and smoking status. MACE was assessed using logistic regression adjusting for hypertension, diabetes mellitus, hyperlipidemia, systemic lupus erythematosus and rheumatoid arthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 579 PG cases. MACE was significantly associated with PG compared to controls, showing (OR, 2.19; 95% CI, 1.47\u22123.27;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in our multivariable model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this nationally representative US cohort, PG was independently associated with increased odds of MACE. These findings highlight the importance of comprehensive cardiovascular screening in patients with PG and support the need for proactive risk management. Further studies exploring the pathophysiological mechanisms underlying this association may help guide more targeted and effective care strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jvc2.70114","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T06:27:46Z","timestamp":1752128866000},"page":"1146-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pyoderma Gangrenosum Associated With Major Adverse Cardiovascular Events"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2929-0207","authenticated-orcid":false,"given":"Nana Ama","family":"Adjei\u2010Frimpong","sequence":"first","affiliation":[{"name":"Department of Dermatology University of California San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Delacqua","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Research Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben A.","family":"Croker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18527"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-021-01440-5"},{"issue":"7","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1056\/NEJMsr1809937","article-title":"The \u2018All of Us\u2019 Research Program","volume":"381","author":"All of Us Research Program Investigators","year":"2019","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314550227"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-021-05768-7"},{"issue":"12","key":"e_1_2_11_7_1","article-title":"Risk of Major Adverse Cardiovascular Events in Patients With Rheumatoid Arthritis","volume":"12","author":"Mal K.","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014402"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.5437"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042440"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.12.035"}],"container-title":["JEADV Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jvc2.70114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jvc2.70114","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jvc2.70114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:08:30Z","timestamp":1772960910000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jvc2.70114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/jvc2.70114"],"URL":"https:\/\/doi.org\/10.1002\/jvc2.70114","archive":["Portico"],"relation":{},"ISSN":["2768-6566","2768-6566"],"issn-type":[{"value":"2768-6566","type":"print"},{"value":"2768-6566","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,9]]},"assertion":[{"value":"2025-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}