{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:03:17Z","timestamp":1791820997906,"version":"4.3.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JEADV Clinical Practice"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic spontaneous urticaria (CSU) is a mast cell\u2010driven condition defined by recurrent wheals and\/or angioedema lasting over 6 weeks without an identifiable trigger. Though CSU is known to co\u2010occur with atopic diseases and share Th2\u2010dominant immunologic pathways, prior studies have not adequately addressed these relationships in diverse populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine associations between CSU and atopic comorbidities in the All of Us (AoU) research program, a diverse, nationwide National Institutes of Health cohort focused on increasing enrollment from historically underrepresented groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a matched, case\u2010control study of AoU participants aged \u2267\u200918 years enrolled between May 6, 2018 and October 1, 2023. CSU cases were identified using SNOMED codes 51611005 and 42265009. Controls were matched 4:1 by age, sex, race, ethnicity, and smoking status. We compared rates of atopic dermatitis, allergic rhinitis, asthma, nasal polyps, food allergy, and drug allergy. Multivariable logistic regression adjusted for hypothyroidism, systemic lupus erythematosus, and rheumatoid arthritis given known associations with CSU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 1171 CSU cases and 4684 matched controls with no significant demographic differences. CSU patients had significantly higher rates of atopic dermatitis (12.6% vs. 1.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), allergic rhinitis (58% vs. 13.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), asthma (46.2% vs. 13.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), nasal polyps (3.8% vs. 0.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and food and drug allergies (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). These associations persisted after multivariable adjustment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates a strong association between CSU and atopic disease in a racially and socioeconomically diverse cohort. Our findings highlight shared Th2\u2010driven pathways underlying CSU and atopy and reinforce the potential utility of type 2 targeted therapies (e.g., dupilumab) in patients with CSU and comorbid atopic disease. Clinicians should screen CSU patients for atopic disease to help guide comprehensive, targeted therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jvc2.70181","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:16:52Z","timestamp":1759987012000},"page":"194-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Atopic Comorbidities Associated With Chronic Spontaneous Urticaria: A Case\u2010Control Analysis of the All of Us Research Program"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8702-3458","authenticated-orcid":false,"given":"Julian A.","family":"Cortes","sequence":"first","affiliation":[{"name":"Department of Dermatology University of California, San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2929-0207","authenticated-orcid":false,"given":"Nana Ama","family":"Adjei\u2010Frimpong","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California, San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savannah K.","family":"Fakhouri","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California, San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Delacqua","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Clinical and Translational Research Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California, San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2120166"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1279976"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000540155"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.926753"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2016.1212660"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13514"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1809937"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patter.2022.100570"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.043"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12673"},{"issue":"8","key":"e_1_2_11_12_1","first-page":"4434","article-title":"Pathogenic Role of Circulating CD4(+)CXCR5(+) Cell Subpopulations in Patients With Chronic Spontaneous Urticarial","volume":"12","author":"Gao C.","year":"2020","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-024-01231-y"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-025-02170-4"}],"container-title":["JEADV Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jvc2.70181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jvc2.70181","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jvc2.70181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:02:42Z","timestamp":1775714562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jvc2.70181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/jvc2.70181"],"URL":"https:\/\/doi.org\/10.1002\/jvc2.70181","archive":["Portico"],"relation":{},"ISSN":["2768-6566","2768-6566"],"issn-type":[{"value":"2768-6566","type":"print"},{"value":"2768-6566","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,8]]},"assertion":[{"value":"2025-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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