{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:23:58Z","timestamp":1778081038126,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":65,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>An association between genetic polymorphisms in encoding X\u2010ray repair cross complementing group 1 (<jats:italic>XRCC1<\/jats:italic>) and encoding xeroderma pigmentosum group D (<jats:italic>XPD<\/jats:italic>) and risks of non\u2010small\u2010cell lung cancer (NSCLC) in East Chinese Han population has been observed. Herein we hypothesized that genetic polymorphisms in these two DNA repair genes are likely to be important in the NSCLC in Chinese nonsmoking female patients. We recruited 327 nonsmoking female patients with NSCLC and 342 individuals with benign lung diseases or healthy controls. Genotype frequencies of <jats:italic>XRCC1<\/jats:italic> T\u201077C, Arg194Trp, Arg280His and Arg399Gln, Pro206Pro, and <jats:italic>XPD<\/jats:italic> Asp312Asn and Lys751Gln were calculated after Polymerase Chain Reaction amplification and sequencing. Generalized multifactor dimensionality reduction (GMDR) was used to detect the interactive effect of <jats:italic>XRCC1<\/jats:italic> and <jats:italic>XPD<\/jats:italic> gene polymorphisms. The ratio of cooking oil mist exposure history and soot exposure history, and the gene frequencies of <jats:italic>XRCC1<\/jats:italic> T\u201077C TC\u2009+\u2009CC, <jats:italic>XRCC1<\/jats:italic> AG\u2009+\u2009GG, <jats:italic>XRCC1<\/jats:italic> 399Gln\/Gln, and <jats:italic>XPD<\/jats:italic> 751Gln\/Gln were higher in female patients with NSCLC than those with benign lung diseases or healthy controls. The haplotypes of <jats:italic>XRCC1<\/jats:italic> T\u2010Arg\u2010Arg\u2010Gln and <jats:italic>XRCC1<\/jats:italic> C\u2010Arg\u2010Arg\u2010Arg were positively associated with the NSCLC occurrence in nonsmoking female patients. GMDR discovered that there was an interactive model of <jats:italic>XRCC1<\/jats:italic> and <jats:italic>XPD<\/jats:italic> genes in multiple gene loci. Logistic regression analysis showed that <jats:italic>XRCC1<\/jats:italic> T\u201077C, <jats:italic>XRCC1<\/jats:italic> Pro206Pro polymorphism, cooking oil mist and soot exposure history and tumor\u2010node\u2010metastasis (TNM) stage were related to NSCLC occurrence for nonsmoking female patients. Taken together, <jats:italic>XRCC1<\/jats:italic> and <jats:italic>XPD<\/jats:italic> polymorphisms, cooking oil mist, and soot exposure history may be interactively correlated with NSCLC incidence for nonsmoking female patients.<\/jats:p>","DOI":"10.1002\/kjm2.12007","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T14:12:34Z","timestamp":1551967954000},"page":"39-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gene polymorphism of DNA repair gene X\u2010ray repair cross complementing group 1 and xeroderma pigmentosum group D and environment interaction in non\u2010small\u2010cell lung cancer for Chinese nonsmoking female patients"],"prefix":"10.1002","volume":"35","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Oncology in Section One Inner Mongolia Chifeng Hospital  Chifeng 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