{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T05:51:21Z","timestamp":1723009881913},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":65,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Health Foundation of Science and Technology Program","award":["2015WSA13002"],"award-info":[{"award-number":["2015WSA13002"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is a common female endocrine disorder that has a detriment impact on female health. Herein, the study used a case\u2010control analysis to sought to explore the association of rs13405728, rs12478601, and rs2479106 single nucleotide polymorphisms (SNPs) with in vitro fertilization and embryo transfer (IVF\u2010ET) efficacy in treating PCOS. A total of 163 PCOS patients (52\u2009cycles) were selected as the PCOS group and 171 patients with tubal factor infertility without PCOS (68\u2009cycles) were selected as the control group. Polymerase chain reaction was used to amplify genome DNA and direct sequencing to detect SNPs. The LHCGR rs13405728, THADA rs12478601, and DENND1A rs2479106 genotypes were subsequently tested. Logistic regression analysis was conducted to analyze the risk factors influencing the occurrence of PCOS as well as those influencing the efficacy of IVF\u2010ET. rs13405728, rs12478601, and family history of DM were influencing factors for the occurrence of PCOS. The rate of abortion and number of oocytes retrieved of patients with the THADA rs12478601 CC genotype increased but the rate of clinical gestation decreased. Patients with AG\u2009+\u2009GG genotype of the DENND1A rs2479106 had increased number of oocytes retrieved, rate of abortion and incidence of gestational DM. rs13405728, rs12478601, serum <jats:italic>E<\/jats:italic><jats:sub>2<\/jats:sub> value as well as fertility rate were influencing factors for efficacy of IVF\u2010ET. It was suggested that the TT genotype of LHCGR rs13405728, CC genotype of THADA rs12478601 and AG\u2009+\u2009GG genotype of DENND1A rs2479106 had poor outcomes of IVF\u2010ET in treating PCOS.<\/jats:p>","DOI":"10.1002\/kjm2.12008","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T14:12:34Z","timestamp":1551967954000},"page":"49-55","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of Rs13405728, Rs12478601, and Rs2479106 single nucleotide polymorphisms and in vitro fertilization and embryo transfer efficacy in patients with polycystic ovarian syndrome: A case control genome\u2010wide association study"],"prefix":"10.1002","volume":"35","author":[{"given":"Jia\u2010Yu","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Gynaecology and Obstetrics Linyi Central Hospital  Linyi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Tian","sequence":"additional","affiliation":[{"name":"Statistical Analysis Centre Linyi Central Hospital  Linyi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui\u2010Hua","family":"Yin","sequence":"additional","affiliation":[{"name":"ICU, Linyi Central Hospital  Linyi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Linyi Central Hospital  Linyi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2012.01.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1687-9856-2011-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719114561552"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.09.024"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113518985"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-012-4357-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167147","article-title":"Influence of TP53 Codon 72 polymorphism alone or in combination with HDM2 SNP309 on human infertility and IVF outcome","volume":"11","author":"Chan Y","year":"2016","journal-title":"PLoS One"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719114561553"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-009-9312-z"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-100"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-015-0606-z"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.732"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.05.057"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des424"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/humrep\/der379","article-title":"Family\u2010based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3","volume":"27","author":"Zhao H","year":"2012","journal-title":"Hum Reprod"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077186","article-title":"Genetic alterations within the DENND1A gene in patients with polycystic ovary syndrome (PCOS)","volume":"8","author":"Eriksen MB","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.08.007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_7_20_1","article-title":"Association study between polycystic ovarian syndrome and the susceptibility genes polymorphisms in Hui Chinese women","volume":"10","author":"Ha L","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_7_21_1","first-page":"441","article-title":"Correlation analysis between polycystic ovary syndrome susceptibility genes and metabolic phenotypes","volume":"49","author":"Sun M","year":"2014","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_7_22_1","first-page":"11883","article-title":"THADA gene variants and polycystic ovary syndrome in a Hainan Chinese population","volume":"9","author":"Bao S","year":"2016","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2013.829446"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2011-100427"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.gene.2015.01.034","article-title":"DENND1A gene variants in Bahraini Arab women with polycystic ovary syndrome","volume":"560","author":"Gammoh E","year":"2015","journal-title":"Gene"},{"key":"e_1_2_7_26_1","first-page":"10964","article-title":"Can the peak E2\/follicle ratio be a quantitative indicator of pregnancy outcomes following assisted reproductive cycles? A retrospective study","volume":"8","author":"Hu D","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des094"}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fkjm2.12008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/kjm2.12008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T07:35:59Z","timestamp":1694676959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/kjm2.12008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/kjm2.12008"],"URL":"https:\/\/doi.org\/10.1002\/kjm2.12008","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"2018-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}