{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:01:47Z","timestamp":1785765707482,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Bone tendon junction injury is hard to cure because of its special anatomical structure, and the treatment applied for bone\u2010tendon junction injury cannot result in the perfect vascular regeneration and restoration of the fibrocartilage zone. In this article, we aim to explore the effect of caveolin\u20101 as a slow\u2010release material on bone\u2010tendon junction healing. Seventy\u2010two New Zealand rabbits were randomly selected and assigned into the experimental, sham\u2010operated and control groups (n\u2009=\u200924). Caveolin\u20101 microspheres and microcapsule were developed as drug delivery system. At the 4th, 8th, and 12th weeks after surgery, quadriceps muscle patella\u2010patellar tendon (QMPPT) was obtained from each rabbit to observe the tendon\u2010to\u2010bone tunnel healing, and X\u2010ray examination, histological examination and biomechanical testing were applied for evaluating new bone formation. As the X\u2010ray showed, caveolin\u20101 increased the new bone area at each time point. At the 4th and 8th weeks after surgery, the rabbit treated with caveolin\u20101 slow release material showed repair of fibrocartilage. According to the biomechanical results, the cross\u2010sectional area, breaking load and ultimate tensile strength were increased along with time. At the same time point, caveolin\u20101 increased the ultimate tensile strength. Our study demonstrates that caveolin\u20101 as a slow\u2010release material could accelerate bone\u2010tendon junction healing by promoting the formation of the transition zone.<\/jats:p>","DOI":"10.1002\/kjm2.12022","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T21:37:22Z","timestamp":1553031442000},"page":"175-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["In vitro effect of caveolin\u20101 as a slow\u2010release material on bone\u2010tendon junction healing: A comparative study"],"prefix":"10.1002","volume":"35","author":[{"given":"Lin\u2010Lin","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The Second People's Hospital in Jiulongpo District Chongqing  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Bing","family":"Su","sequence":"additional","affiliation":[{"name":"Department 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