{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:24:23Z","timestamp":1770956663345,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T00:00:00Z","timestamp":1553558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Hebei province Commission of Population and Family Planning","award":["20180749"],"award-info":[{"award-number":["20180749"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cadmium sulfide nanoparticle (Nano\u2010CdS) is a kind of important semiconductor material with special photochemistry property. With the Nano\u2010CdS being widely used, the security problems it caused have been catching more and more attention. This study aims to explore the possible mechanism of liver injury induced by Nano\u2010CdS and whether resveratrol can reduce the damage. In this study, male BALB\/C mice were treated with Nano\u2010CdS with a diameter of 20 to 30\u2009nm and a length of 80 to 100\u2009nm. It turned out that the mice liver inflammatory cells infiltrated, the liver tissue and the ultrastructure changed; The activities of T\u2010AOC and GSH were suppressed (n\u2009=\u20096, <jats:italic>P<\/jats:italic> &lt; 0.05) and the content of lipid peroxide (MDA) increased (n\u2009= 6, <jats:italic>P<\/jats:italic> &lt; 0.05). Besides, Nano\u2010CdS decreased the mRNA expression level of Sirt1 and FoxO1 genes in liver tissue (n\u2009= 3, <jats:italic>P<\/jats:italic> &lt; 0.05). All the changes in the index were reversed by resveratrol. The mRNA expression level of FoxO3a showed no significant difference between the control group and the Nano\u2010CdS group. But under the protection of resveratrol, the mRNA expression level of FoxO3a was higher than that in the control and Nano\u2010CdS groups (n\u2009= 3, <jats:italic>P<\/jats:italic> &lt; 0.05). Results suggest that Nano\u2010CdS can cause oxidative damages to liver tissues in mice, in which process that the Sirt1 and FoxO1 genes may participate, and the damage can be reversed by resveratrol which may be a potential cure for oxidative damage to nanomaterials.<\/jats:p>","DOI":"10.1002\/kjm2.12056","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T20:31:16Z","timestamp":1553632276000},"page":"297-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Resveratrol alleviate the injury of mice liver induced by cadmium sulfide nanoparticles"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-1030","authenticated-orcid":false,"given":"Chun\u2010Yan","family":"Meng","sequence":"first","affiliation":[{"name":"Laboratory of Coal Mine Health and Safety School of Public Health, North China University of Science and Technology  Tangshan Hebei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Feng","family":"Han","sequence":"additional","affiliation":[{"name":"The section of Infectious Disease Control, Tianjin Hebei District Center for Disease Control and Prevention  Tianjin PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Coal Mine Health and Safety School of Public Health, North China University of Science and Technology  Tangshan Hebei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Xia","family":"Gao","sequence":"additional","affiliation":[{"name":"Laboratory of Coal Mine Health and Safety School of Public Health, North China University of Science and Technology  Tangshan Hebei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Yi","family":"Ren","sequence":"additional","affiliation":[{"name":"Laboratory of 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