{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:27:33Z","timestamp":1782901653354,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002811","name":"Cathay General Hospital","doi-asserted-by":"publisher","award":["CGH\u2010MR\u20109306"],"award-info":[{"award-number":["CGH\u2010MR\u20109306"]}],"id":[{"id":"10.13039\/501100002811","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["NSC 92\u20103112\u2010B\u2010242\u2010001"],"award-info":[{"award-number":["NSC 92\u20103112\u2010B\u2010242\u2010001"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Variations at the six nucleotides \u22123279 (T\u2009&gt;\u2009G), \u221253 (A[TA]<jats:sub>6<\/jats:sub>TAA\u2009&gt;\u2009A[TA]<jats:sub>7<\/jats:sub>TAA), 211 (G\u2009&gt;\u2009A), 686 (C\u2009&gt;\u2009A), 1091 (C\u2009&gt;\u2009T), and 1456 (T\u2009&gt;\u2009G) in the UDP\u2010glucuronosyltransferase 1A1 (<jats:italic>UGT1A1<\/jats:italic>) gene were determined in 178 Taiwanese patients with Gilbert's syndrome and in 200 healthy adults. Every subject was classified as a genotype depending on variation status of the six nucleotides in the <jats:italic>UGT1A1<\/jats:italic> gene. The UGT1A1 activity for each genotype was calculated and then those genotypes were divided into 10 subgroups (Q1~Q10) according to their UGT1A1 activities, by using 10% as an interval. There were 24 genotypes observed, with UGT1A1 activity ranged 9%~100% of normal. There were two and six subjects with Gilbert's syndrome and none of healthy controls carrying genotypes in the Q1 and Q2 subgroups, respectively. The odds of developing Gilbert's syndrome were significantly higher for subjects carrying genotypes in the Q3, Q4, and Q5 subgroups than for those with genotype in the Q10 subgroup (odds ratios: 240.22, 59.80, and 14.67, respectively, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001 for each). Among the 178 patients of Gilbert's syndrome, serum bilirubin value was inversely correlated with UGT1A1 activity (r\u2009=\u2009\u2212.306, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The sensitivity was 72.0% and the specificity was 90.5% by using UGT1A1 activity \u226640% of normal as the cut\u2010off point to distinguish between healthy subjects and patients of Gilbert's syndrome. Our results demonstrate that UGT1A1 activity is certainly a determinate for serum bilirubin value and UGT1A1 activity \u226640% of normal is a proper risk factor for the development of Gilbert's syndrome.<\/jats:p>","DOI":"10.1002\/kjm2.12077","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T15:46:43Z","timestamp":1556120803000},"page":"432-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of UDP\u2010glucuronosyltransferase 1A1 activity on risk for developing Gilbert's syndrome"],"prefix":"10.1002","volume":"35","author":[{"given":"May\u2010Jen","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology Cathay General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Changhua Christian Medical Foundation Changhua Christian Hospital  Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang\u2010Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Cathay General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sien\u2010Sing","family":"Yang","sequence":"additional","affiliation":[{"name":"Liver Unit Cathay General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Lain","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology Central Taiwan University of Science and Technology  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-9995","authenticated-orcid":false,"given":"Ching\u2010Shan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical 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