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LNM of papillary thyroid carcinoma are a plausible prognostic factor to determine disease recurrence. Currently, fine needle lymph node aspiration for cytology (LN\u2010FN\u2010cytology) is the best modality to diagnose LNM but is limited by diagnostic sensitivity and sample error. Fine needle lymph node aspiration for thyroglobulin measurement (LN\u2010FNA\u2010Tg) could offer a reliable and quantitative diagnostic method for LNM. The combination of LN\u2010FNA\u2010cytology and LN\u2010FNA\u2010Tg could achieve almost 100% diagnostic sensitivity and specificity for LNM. Both treatment guidelines of the American Thyroid Association and European Thyroid Association recommend LN\u2010FNA\u2010Tg to diagnose LNM after total thyroidectomy. Diagnostic accuracy of the LN\u2010FNA\u2010Tg depends on optimal equipment, scanning protocol, skill, and experience of operators. Normal saline is mainly used for aspiration needle wash\u2010out and buffer solution. And radioimmunoassay or immunoradiometric assay are widely used for the LN\u2010FNA\u2010Tg measurement. So far, there is no consensus about the diagnostic threshold of LN\u2010FNA\u2010Tg for positive LNM, but high LN\u2010FNA\u2010Tg, especially higher than 10 ng\/mL, strongly favors LNM.<\/jats:p>","DOI":"10.1002\/kjm2.12173","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T06:46:22Z","timestamp":1578379582000},"page":"236-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Clinical application of the ultrasound\u2010guided fine needle aspiration for thyroglobulin measurement to diagnose lymph node metastasis from differentiated thyroid carcinoma\u2010literature review"],"prefix":"10.1002","volume":"36","author":[{"given":"He\u2010Jiun","family":"Jiang","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung 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