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In the present study, OTUB2 was found significantly upregulated in liver cancer tumor tissues and cell lines, and elevated OTUB2 indicated as a negative index for the overall survival of liver cancer patients. At the cellular level, knockdown of OTUB2 markedly inhibited liver cancer cell growth. Our further investigations revealed that knockdown of OTUB2 significantly suppressed NF\u2010\u03baB\u2010driving luciferase activity, and markedly inhibited the phosphorylation of NF\u2010\u03baB p65 in liver cancer cells, which indicated that OTUB2 mediated liver cancer cell growth by regulating NF\u2010\u03baB signaling. Additionally, we found that liver cancer cell lines harboring higher OTUB2 expression were more sensitive to NF\u2010\u03baB inhibitors, and overexpression of OTUB2 could significantly reduce the antitumor effects of NF\u2010\u03baB inhibitors in liver cancer cells. This study indicated that OTUB2 could be a promising target for the treatment of liver cancer in the future.<\/jats:p>","DOI":"10.1002\/kjm2.12187","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T13:15:46Z","timestamp":1580476546000},"page":"399-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF\u2010\u03baB signaling"],"prefix":"10.1002","volume":"36","author":[{"given":"Zhen\u2010Lin","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University  Huaian Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Affiliated Huaian No.1 People's Hospital of Nanjing 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