{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:30:02Z","timestamp":1793298602292,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Platelet concentrates have emerged as innovative autologous blood products that enhance tissue healing and regeneration in regenerative therapy. A common feature of these products is their higher than baseline platelet concentration, which improves wound healing and tissue repair. Four main categories of products can be easily defined, based on their leukocyte content and fibrin architecture: pure platelet\u2010rich plasma, such as Cell Separator PRP or Anitua' PRGF; leukocyte\u2010 and platelet\u2010rich plasma (L\u2010PRP), such as PCCS or Ace PRP; pure platelet\u2010rich fibrin (P\u2010PRF), such as Fibrinet PRFM; and leukocyte\u2010 and platelet\u2010rich fibrin (L\u2010PRF), such as Choukroun's PRF. Two families contain significant concentrations of leukocytes: L\u2010PRP and L\u2010PRF. These four families of products have different biological signatures and mechanisms and obviously different clinical applications. An L\u2010PRF membrane releases growth factors and matrix proteins over a period longer than 7\u2009days, whereas a PRP gel matrix releases and disperses its growth factors in a relatively quick download. In the near future, simple and inexpensive products such as L\u2010PRF are expected to have applications in oral\u2010maxillofacial surgery, periodontal surgery, plastic surgery, orthopedic surgery, and sports medicine. Leukocytes substantially affect the intrinsic biology and properties of platelet concentrates, not only because they enhance immune function and antibacterial potential, but also because they have essential roles in the wound healing process. Unfortunately, their impact has been almost completely neglected in the literature. Improved understanding of the effects of leukocytes in wound healing is essential for development of new clinical applications of platelet concentrates.<\/jats:p>","DOI":"10.1002\/kjm2.12192","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:53:01Z","timestamp":1581555181000},"page":"305-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Autologous platelet concentrates in maxillofacial regenerative therapy"],"prefix":"10.1002","volume":"36","author":[{"given":"Tsau\u2010Mau","family":"Chou","sequence":"first","affiliation":[{"name":"School of Dentistry and Graduate Program of Dental Science College of Dental Medicine, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Dentistry Kaohsiung Medical University Hospital  Kaohsiung 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