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Most related studies have used functional magnetic resonance imaging to investigate brain areas involved in migraine. However, the results are heterogeneous. In this study, we used a convenient tool to explore the brain regions involved in migraine. In this study, 40 children with migraine and 40 sex\u2010 and age\u2010matched health controls were enrolled, and electroencephalogram was used to explore the functional abnormal areas of migraine through electroencephalogram bands and low\u2010resolution electromagnetic tomography analysis. The results revealed that spectrum edge frequency 50 in all electroencephalogram channels in patients with migraine were lower than those in controls. Significant differences were discovered over frontal areas. In addition, significantly higher current density over the frontopolar prefrontal cortex and orbitofrontal cortex and higher connectivity over the left prefrontal cortex were observed in patients with migraine. We suggest that functional disturbance of the prefrontal cortex may play a potential role in children with migraine, and that low\u2010resolution electromagnetic tomography is a reliable and convenient tool for studying the functional disturbance of migraine.<\/jats:p>","DOI":"10.1002\/kjm2.12213","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T16:06:01Z","timestamp":1586275561000},"page":"543-551","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quantitative electroencephalogram analysis of frontal cortex functional changes in patients with migraine"],"prefix":"10.1002","volume":"36","author":[{"given":"Chen\u2010Sen","family":"Ouyang","sequence":"first","affiliation":[{"name":"Department of Information Engineering I\u2010Shou University  Kaohsiung, Taiwan, 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