{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:48:21Z","timestamp":1774126101065,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute lung injury (ALI) caused by gas explosion is common, and warrants research on the underlying mechanisms. Specifically, the role of abnormalities of coagulation and fibrinolysis in this process has not been defined. It was hypothesized that the abnormal coagulation and fibrinolysis promoted ALI caused by gas explosion. Based on the presence of ALI, 74 cases of gas explosion injury were divided into the ALI and non\u2010ALI groups. The results of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), and platelet count (PLT) were collected within 24\u2009hours and compared between the groups. ALI models caused by gas explosion were established in Sprague Dawley rats, and injuries were evaluated using hematoxylin and eosin (HE) staining and histopathological scoring. Moreover, the bronchoalveolar lavage fluid (BALF) was collected to examine thrombin\u2010antithrombin complex (TAT), tissue factor (TF), tissue factor pathway inhibitor (TFPI), and plasminogen activator inhibitor\u20101 (PAI\u20101) levels by enzyme\u2010linked immunosorbent assay (ELISA). The patients in ALI group had shorter PT and longer APTT, raised concentration of FIB and decreased number of PLT, as compared to the non\u2010ALI group. In ALI rats, the HE staining revealed red blood cells in alveoli and interstitial thickening within 2\u2009hours which peaked at 72\u2009hours. The levels of TAT\/TF in the BALF increased continually until the seventh day, while the PAI\u20101 was raised after 24\u2009hours and 7\u2009days. The TFPI was elevated after 2 hours and 24\u2009hours, and then decreased after 72\u2009hours. Abnormalities in coagulation and fibrinolysis in lung tissues play a role in ALI caused by gas explosion.<\/jats:p>","DOI":"10.1002\/kjm2.12262","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T10:01:58Z","timestamp":1594288918000},"page":"929-936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The abnormalities of coagulation and fibrinolysis in acute lung injury caused by gas explosion"],"prefix":"10.1002","volume":"36","author":[{"given":"Lin\u2010Qiang","family":"Tian","sequence":"first","affiliation":[{"name":"Institute of Trauma and Orthopedics Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Hao","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Orthopedics Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Zheng","family":"Meng","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Orthopedics Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Orthopedics Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Orthopedics Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Hang","family":"Yin","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Orthopedics Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Lai","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Orthopedics Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Orthopedics Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Li","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Orthopedics Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang\u2010Fang","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Orthopedics Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Zhou","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Orthopedics Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"San\u2010Qiao","family":"Yao","sequence":"additional","affiliation":[{"name":"Public Health College Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Dong","family":"Wu","sequence":"additional","affiliation":[{"name":"Public Health College Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Gang","family":"Weng","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Orthopedics Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-9430","authenticated-orcid":false,"given":"Wen\u2010Jie","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Trauma and Orthopedics Xinxiang Medical University  Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2018.09.059"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2013.09.070"},{"key":"e_1_2_7_4_1","first-page":"102","article-title":"Research on spatiotemporal regularity of coal mine safety accidents in China during last decade","volume":"43","author":"Tan ZL","year":"2017","journal-title":"China Coal"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2018.03.052"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.1.165"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000070739.34700.f6"},{"key":"e_1_2_7_8_1","first-page":"170","article-title":"Clinical analysis of 106 cases of inhalation injury induced by gas explosion","volume":"16","author":"You GF","year":"2000","journal-title":"Chin J Burns"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.03.024"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-019-0187-z"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.04.028"},{"key":"e_1_2_7_12_1","first-page":"32","article-title":"Influences of ulinastatin on acute lung injury and time phase changes of coagulation parameters in rats with burn\u2010blast combined injuries","volume":"34","author":"Liu W","year":"2018","journal-title":"Chin J Burns"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.12.020"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00429.2015"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0210ST"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc7026"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2016.1317"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04167.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2019.1584829"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25458"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2352-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccl.2016.08.001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09150-9"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1990.tb00111.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2019.1581921"},{"key":"e_1_2_7_26_1","first-page":"281","article-title":"Significance of evaluating the severity of patients with extremely severe burn by platelet count recovery in the early stage post burn","volume":"33","author":"Wu Y","year":"2017","journal-title":"Chin J Burns"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-841593"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.014530"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2741\/4613"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2017.1306045"},{"key":"e_1_2_7_31_1","first-page":"961784","article-title":"Bronchoalveolar activation of coagulation and inhibition of fibrinolysis during ventilator\u2010associated lung injury","volume":"2012","author":"Schultz MJ","year":"2012","journal-title":"Crit Care Res Pract"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31820f85a7"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.01.015"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-12-1053"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12047"}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fkjm2.12262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/kjm2.12262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/kjm2.12262","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/kjm2.12262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T02:19:25Z","timestamp":1693880365000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/kjm2.12262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,9]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/kjm2.12262"],"URL":"https:\/\/doi.org\/10.1002\/kjm2.12262","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,9]]},"assertion":[{"value":"2019-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}