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The potential effect of miR\u2010451a in AH mice was examined in the current study. A mice AH model was established and the miR\u2010451a expression in AH mice compared with the sham group was tested by real\u2010time polymerase chain reaction (qRT\u2010PCR). AH mice were injected with pre\u2010miR\u2010451a lentivirus for miR\u2010451a overexpression and histone deacetylase (HDAC8) lentivirus for HDAC8 overexpression in AH mice. The underlying mechanisms were explored by searching the potential target genes of miR\u2010451a in miRanda database and then we confirmed this. We found that miR\u2010451a expression was significantly decreased in AH mice compared with the sham group. Moreover, miR\u2010451a overexpression alleviated alcohol\u2010induced liver inflammation and injuries of AH mice. Additionally, further mechanism exploration disclosed that HDAC8 was a target of miR\u2010451a. The protective effect of miR\u2010451a on AH in AH mice was abolished by HDAC8 overexpression. In summary, miR\u2010451a ameliorates AH via repressing HDAC8\u2010mediated proinflammatory response.<\/jats:p>","DOI":"10.1002\/kjm2.12272","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T10:05:40Z","timestamp":1594289140000},"page":"904-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>MiR<\/scp>\u2010451a ameliorates alcoholic hepatitis via repressing <scp>HDAC8<\/scp>\u2010mediated proinflammatory response"],"prefix":"10.1002","volume":"36","author":[{"given":"Bo","family":"Du","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery The People's Hospital of Kaizhou District  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Hong","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery The People's Hospital of Kaizhou District  Chongqing 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