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Eliminating hepatitis C virus (HCV) can greatly improve long\u2010term outcomes. Several direct\u2010acting antiviral agents (DAAs), including sofosbuvir (SOF) plus different NS5A inhibitors, as well as non\u2010SOF\u2010based DAAs, including glecaprevir\/pibrentasvir (GLE\/PIB), have been approved for treating CHC genotype\u20102 (GT\u20102) patients in Taiwan. However, there is limited real\u2010world effectiveness data regarding these different regimens. Thus, we aimed to evaluate the real\u2010world efficacy in CHC GT\u20102 patients who underwent these DAA regimens. We retrospectively enrolled CHC GT\u20102 patients who were treated with SOF\u2010based DAAs or GLE\/PIB at a single medical center. A total of 704 enrolled patients were treated with either SOF\u2009+\u2009ribavirin (RBV), SOF\/daclatasvir (DCV)\u2009\u00b1\u2009RBV, SOF\/ledipasvir (LDV)\u2009\u00b1\u2009RBV, SOF\/velpatasvir (VEL)\u2009\u00b1\u2009RBV, or with GLE\/PIB. The overall sustained virological response (SVR) rate was 97.9%. The SVR rate was significantly lower in the SOF\u2009+\u2009RBV group (95.6%) than in the non\u2010SOF\u2009+\u2009RBV (98.9%) group, especially compared to the SOF\/DCV (100%) and GLE\/PIB groups (99.5%). Among patients treated with SOF\u2009+\u2009RBV, cirrhotic patients had significantly lower SVR rates than noncirrhotic patients (89.4% vs 98.2%). Multivariate analysis showed that patients with a younger age, hepatitis B virus coinfection, baseline cirrhosis, or those who received SOF\u2009+\u2009RBV were less likely to achieve SVR. In conclusion, for CHC GT\u20102 patients, SOF in combination with DCV, LDV, or VEL, as well as GLE\/PIB, achieved similar high efficacies, regardless of cirrhosis, treatment experience, or chronic kidney disease status. Therefore, the use of DAA therapy to eradicate HCV should not be delayed in these populations.<\/jats:p>","DOI":"10.1002\/kjm2.12315","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T11:42:20Z","timestamp":1604576540000},"page":"334-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Real\u2010world effectiveness of direct\u2010acting antiviral agents for chronic hepatitis C patients with genotype\u20102 infection after completed treatment"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0158-969X","authenticated-orcid":false,"given":"Tzu\u2010Sheng","family":"Cheng","sequence":"first","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung 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