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However, the regulatory function and involvement of SP1\u2010induced lncRNA DANCR in ovarian cancer remain elusive. Data from this study showed that SP1 was up\u2010regulated in ovarian cancer tissues and cells (CAOV3, SKOV3, A2780), and SP1 could bind to the promoter region of DANCR through chromatin immunoprecipitation and leuciferase activity assays. Therefore, DANCR was transcriptionally induced by SP1 in ovarian cancer tissues and cells (CAOV3, SKOV3, A2780). Functionally, reduced expression of DANCR suppressed cell viability, migration and invasion of CAOV3, while enhanced DANCR expression contributed to SKOV3 growth. Over\u2010expression of SP1 reversed the suppressive effects of DANCR interference on ovarian cancer progression. In conclusion, SP1\u2010induced DANCR contributed to oncogenic potential of ovarian cancer, suggesting a promising therapeutic target for ovarian cancer.<\/jats:p>","DOI":"10.1002\/kjm2.12316","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T14:13:10Z","timestamp":1603375990000},"page":"371-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<scp>SP1<\/scp>\u2010induced <scp>lncRNA DANCR<\/scp> contributes to proliferation and invasion of ovarian cancer"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3239-0501","authenticated-orcid":false,"given":"Peng\u2010Hua","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Gynecology Affiliated Hospital of Chengde Medical University  Chengde City Hebei Province 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