{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:28:44Z","timestamp":1791808124087,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gallbladder carcinoma (GBC) commonly occurs in gastrointestinal malignancy and has the fifth highest mortality rate among gastrointestinal malignancy. Recently, miR\u2010188\u20105p, a small noncoding RNA, has been implicated in various types of cancer such as nasopharyngeal carcinoma, oral squamous cell carcinoma, liver cancer, and prostate cancer. However, the effect of miR\u2010188\u20105p on GBC remains unclear. Here, we demonstrated that miR\u2010188\u20105p was downregulated in GBC tissues, and downregulation of miR\u2010188\u20105p correlated with larger tumor size, lymph node metastasis, and extensive metastasis. In addition, the overall survival time of patients with higher miR\u2010188\u20105p expression was significantly longer than that of patients with low\u2010miR\u2010188\u20105p expression. Moreover, downregulation of miR\u2010188\u20105p promoted the proliferation, migration, and invasion of GBC cells, while its overexpression inhibited cell invasion and induced cell apoptosis, and arrested GBC growth in vivo. Importantly, miR\u2010188\u20105p\u2010dependent tumorigenesis was correlated with Wnt\/\u03b2\u2010catenin signaling and p\u201038\/JNK signaling. In conclusion, miR\u2010188\u20105p plays a direct role in GBC tumorigenesis. Our study suggests that miR\u2010188\u20105p could serve as a novel diagnosis marker and therapeutic target in GBC.<\/jats:p>","DOI":"10.1002\/kjm2.12323","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T07:01:37Z","timestamp":1606287697000},"page":"294-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<scp>miR<\/scp>\u2010188\u20105p inhibits proliferation, migration, and invasion in gallbladder carcinoma by targeting Wnt2b and Smad2"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4904-1212","authenticated-orcid":false,"given":"Xiang\u2010Lu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ward 1 of Oncology Hainan General Hospital  Haikou City 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