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Hyper proliferation, infiltration of inflammatory cells and aberrant differentiation of keratinocytes are the three most important characteristics of psoriasis. Previous reports showed that NF\u2010\u03baBis the crucial mediator linking psoriatic keratinocytes and immune cell states through its effects on chemokine and cytokine production. To identify the role of NF\u2010\u03baB in psoriasis, we conducted ELISA assay to detect the activity of NF\u2010\u03baB in lesional skin and nonlesional skin of patients with psoriasis. Mounting evidence suggests that the interaction between long noncoding RNAs (lncRNAs) and microRNAs plays important role in the regulation of the initiation and development of various diseases. In this article, we identified that lncRNA UCA1 was down\u2010regulated in lesional skin of patients with psoriasis. Further studies showed that lncRNA UCA1 could promote the expression of A20 by inhibitingmiR125a, and up\u2010regulated A20 decreased the activity of NF\u2010\u03baB through its ubiquitin editing function. Taken together, we identified and demonstrated that lncRNA UCA1 negatively regulated NF\u2010\u03baB activity in psoriasis through the miR125a\u2010A20 axis.<\/jats:p>","DOI":"10.1002\/kjm2.12363","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T05:30:14Z","timestamp":1612848614000},"page":"172-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>LncRNA UCA1<\/scp> negatively regulates <scp>NF\u2010kB<\/scp> activity in psoriatic keratinocytes through the <scp>miR125a\u2010A20<\/scp> axis"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7108-3956","authenticated-orcid":false,"given":"Xiao\u2010Lei","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking University International Hospital  Beijing 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