{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:42:15Z","timestamp":1775857335344,"version":"3.50.1"},"reference-count":76,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Over the past decades, marked advancement has been made in the prevention and treatment of hepatitis B virus (HBV) infection. Due to highly effective antiviral therapies for chronic hepatitis B (CHB), long\u2010term clinical outcomes in patients with CHB has also been dramatically improved. However, current antiviral therapies for CHB cannot completely abolish the risk of hepatocellular carcinoma (HCC). In addition, current treatment guidelines for CHB should be interpreted with caution given that HBV\u2010associated hepatocarcinogenesis could be underway in patients who are not eligible for antiviral therapies by current guidelines. Therefore, efforts to reconcile treatment guidelines with recent clinical evidence should be made for reducing further development of HCC. In this article, we review the secondary prevention of HBV\u2010related HCC with current antiviral therapies.<\/jats:p>","DOI":"10.1002\/kjm2.12364","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T15:40:45Z","timestamp":1611762045000},"page":"262-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Secondary prevention of hepatitis B <scp>virus\u2010related<\/scp> hepatocellular carcinoma with current antiviral therapies"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7470-5850","authenticated-orcid":false,"given":"Jonggi","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1544-577X","authenticated-orcid":false,"given":"Young\u2010Suk","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61412-X"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30056-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32154-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.3055"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30204-3"},{"key":"e_1_2_11_7_1","article-title":"Epidemiology of hepatocellular carcinoma","author":"McGlynn KA","year":"2020","journal-title":"Hepatology"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl19024"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29321"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.05.021"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2017.0104"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.276701"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.05.048"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290312"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033364"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0049"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13244"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9675-4"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2019.1002"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.1.65"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314904"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.036"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300937"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306409"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15311"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.07.022"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2008.00989.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.075"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02491.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12590"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15725"},{"issue":"1","key":"e_1_2_11_34_1","first-page":"162A","article-title":"A randomized placebo\u2010controlled trial of tenofovir disoproxil fumarate in chronic hepatitis B patients with minimally elevated aminotransferase","volume":"68","author":"Hsu YC","year":"2018","journal-title":"Hepatology"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004433"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13774"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2018.0040"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23505"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.248"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.07.023"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.065136"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28156"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70077-8"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16097"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15741"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.09.034"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00833-10"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.009"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.07.012"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.12.003"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070910"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12380"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0618-8278(19)30145-8"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.02.033"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.07.010"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4070"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.09.025"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.03.028"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318947"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000428"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.02.046"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.06.011"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.05.008"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30249-1"},{"key":"e_1_2_11_66_1","first-page":"126a","article-title":"Impact of treatment with tenofovir alafenamide (Taf) or tenofovir disoproxil fumarate (Tdf) on hepatocellular carcinoma (Hcc) incidence in patients with chronic hepatitis B (Chb)","volume":"70","author":"Lim YS","year":"2019","journal-title":"Hepatology"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.11.045"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23641"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1075"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.0035"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321309"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30107-8"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30024-3"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.039"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31000-2"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0093-9"},{"key":"e_1_2_11_77_1","article-title":"High level of medication adherence is required to lower mortality in patients with chronic hepatitis B taking entecavir: a nationwide cohort study","author":"Lee J","year":"2020","journal-title":"J Viral Hepat"}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/kjm2.12364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/kjm2.12364","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/kjm2.12364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T20:08:49Z","timestamp":1693598929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/kjm2.12364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,27]]},"references-count":76,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/kjm2.12364"],"URL":"https:\/\/doi.org\/10.1002\/kjm2.12364","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,27]]},"assertion":[{"value":"2020-12-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}