{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:23Z","timestamp":1786978283314,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multidrug resistance (MDR) of chemotherapy is one of the significant concerns in cancer therapy. Here in our study, cisplatin (DDP) and oleanolic acid (OA) were co\u2010loaded in mesoporous silica nanoparticles (Nsi) to construct DDP\/OA\u2010Nsi and solve the DDP\u2010resistance in lung cancer therapy. The cytotoxicity and apoptosis assays demonstrated that in DDP\u2010resistant A549\/DDP cells, the cytotoxicity of DDP\/OA\u2010Nsi was significantly higher than that of free DDP or DDP single delivery system (DDP\u2010Nsi). The intracellular drug accumulation study revealed that the intracellular DDP concentration in the DDP\/OA\u2010Nsi group was also higher than that in free DDP and DDP\u2010Nsi groups. In the A549\/DDP xenograft tumor model, DDP\/OA\u2010Nsi showed the best anticancer effect. In summary, DDP\/OA\u2010Nsi was a promising drug delivery system to solve MDR in lung cancer therapy.<\/jats:p>","DOI":"10.1002\/kjm2.12365","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T10:09:44Z","timestamp":1612951784000},"page":"505-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Co\u2010delivery of cisplatin and oleanolic acid by silica nanoparticles\u2010enhanced apoptosis and reverse multidrug resistance in lung cancer"],"prefix":"10.1002","volume":"37","author":[{"given":"Xiao\u2010Kai","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Thoracic Oncosurgery\u20102 Jilin Province Tumor Hospital  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncosurgery\u20102 Jilin Province Tumor Hospital  Changchun 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