{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:48:10Z","timestamp":1781272090921,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Asthma is regarded as a chronic inflammation of the airway. Research has highlighted the significance of Vitamin D in asthma. This study explored the mechanism of vitamin D on asthma. The asthma mouse model was established by ovalbumin (OVA) sensitization and treated with vitamin D (50 or 100\u2009ng\/ml). The morphological changes of the airway were observed by HE staining. The serum IgE contents and MDA, ROS, and SOD expressions in the bronchoalveolar lavage fluid (BALF) were detected by ELISA. The Th17 and Treg cells were detected using flow cytometry. The ROR\u03b3t and Foxp 3 expressions were detected by Reverse transcription quantitative polymerase chain reaction (RT\u2010qPCR). IL\u201017, IL\u201010, and TGF\u2010\u03b21 expressions were detected using ELISA. The NF\u2010\u03baB pathway was blocked using the NF\u2010\u03baB pathway inhibitor, Andrographolide sulfonate. The NF\u2010\u03baB pathway\u2010related indexes were detected by western blotting. After blockade of the NF\u2010\u03baB pathway, the IL\u201017, IL\u201010, and TGF\u2010G1 expressions were detected. OVA\u2010sensitized asthma induced airway remodeling and elevated IgE content in mice, which was downregulated after vitamin D treatment. MDA and ROS were upregulated and SOD was downregulated in asthmatic mice, while vitamin D inverted the changes. Th17\/Treg ratio was imbalanced, ROR\u03b3t and IL\u201017 were upregulated, and Foxp 3, IL\u201010, and TGF\u2010\u03b21 were downregulated after OVA sensitization, while vitamin D treatment inverted these changes and inhibited the NF\u2010\u03baB\u2010p65 phosphorylation level. After blockade of the NF\u2010\u03baB pathway, IL\u201017 was downregulated and IL\u201010 and TGF\u2010\u03b21 were upregulated. In conclusion, vitamin D rectified the Th17\/Treg balance and alleviated airway inflammation by inhibiting the NF\u2010\u03baB pathway in asthmatic mice.<\/jats:p>","DOI":"10.1002\/kjm2.12441","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T18:14:14Z","timestamp":1630347254000},"page":"1113-1121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Vitamin D has an effect on airway inflammation and Th17\/Treg balance in asthmatic mice"],"prefix":"10.1002","volume":"37","author":[{"given":"Jing\u2010Guo","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Pediatric Puren Hospital Affiliated to Wuhan University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Ji","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Puren Hospital Affiliated to Wuhan University 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