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This study evaluated lncRNA myocardial infarction\u2010associated transcription (MIAT) expression in CAD patients and its clinical significance. Totally, 155 CAD patients and 76 non\u2010CAD controls were enrolled. MIAT expression was detected using reverse transcription quantitative polymerase chain reaction. The clinical diagnostic significance of MIAT was evaluated by plotting the receiver operating characteristic (ROC) curve. The levels of inflammatory cytokines were detected using enzyme\u2010linked immunosorbent assay. microRNA (miR)\u201029b\u20103p expression and pregnancy\u2010associated plasma protein A (PAPPA) level were detected. MIAT expression in CAD patients (4.23 [1.22\u20136.50]) was higher than that in non\u2010CAD controls (1.64 [0.05\u20132.93]) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and had an independent correlation with CAD. The area under ROC curve of predicting CAD was calculated as 0.790, the specificity as 71.40%, and the sensitivity as 70.00%. MIAT expression was positively correlated with the C\u2010reactive protein level (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.769, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and pro\u2010inflammatory cytokines tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin 6 (IL\u20106), and IL\u20108 levels, while negatively correlated with the anti\u2010inflammatory cytokine IL\u201010. MIAT was positively correlated with Gensini score and had an independent correlation with it. LncRNA MIAT sponged miR\u201029b\u20103p and miR\u201029b\u20103p targeted PAPPA. In conclusion, lncRNA MIAT was upregulated in the peripheral blood of CAD patients and elicited clinical diagnostic significance. MIAT participated in the development of CAD via miR\u201029b\u20103p\/PAPPA axis. This study provides insights into a potential target for the diagnosis and treatment of CAD.<\/jats:p>","DOI":"10.1002\/kjm2.12444","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T23:42:14Z","timestamp":1632526934000},"page":"1038-1047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Upregulation of long non\u2010coding RNA myocardial infarction\u2010associated transcription is correlated with coronary artery stenosis and elevated inflammation in patients with coronary atherosclerotic heart disease"],"prefix":"10.1002","volume":"37","author":[{"given":"Zhi\u2010Sheng","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery The Affiliated Hospital of Qingdao University  Qingdao 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