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This study showed that the abilities of cell migration, invasion, and epithelial\u2013mesenchymal transition (EMT) were attenuated in ASPM\u2010deficient CRC cell lines. Furthermore, we reported that attenuation of ASPM expression inhibited CRC cell metastasis in vivo. Additionally, the expression of ASPM was positively correlated with \u03b2\u2010catenin level in CRC tissues. Mechanistically, ASPM can upregulate \u03b2\u2010catenin transcription by stimulating the \u03b2\u2010catenin promoter and enhancing the nuclear translocation of \u03b2\u2010catenin in CRC cells, which leads to the activation of the Wnt\/\u03b2\u2010catenin pathway. Finally, we showed that ASPM effectively induced CRC cell migration and invasion in a \u03b2\u2010catenin\u2010dependent manner.<\/jats:p>","DOI":"10.1002\/kjm2.12464","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T07:45:24Z","timestamp":1636184724000},"page":"129-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<scp>ASPM<\/scp> facilitates colorectal cancer cells migration and invasion by enhancing \u03b2\u2010catenin expression and nuclear translocation"],"prefix":"10.1002","volume":"38","author":[{"given":"Lu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First People's Hospital of Lianyungang  Lianyungang China"},{"name":"Department of Gastroenterology The First Affiliated Hospital of Kangda College of Nanjing Medical University  Lianyungang 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