{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:29:04Z","timestamp":1790022544760,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG8H0761"],"award-info":[{"award-number":["CMRPG8H0761"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To determine whether liver stiffness (LS) and fibrosis\u20104 (Fib\u20104) index were useful in assessing the occurrence of liver\u2010related complications (LRC) in chronic hepatitis C (CHC) patients after direct\u2010acting antivirals (DAAs) had been administered. This retrospective study enrolled CHC patients achieving sustained virological response (SVR) after DAA. A total of 697 (male\/female: 294\/403, mean age: 63.8\u00a0year) patients with measured LS and complete lab data at SVR were enrolled, followed, and analyzed. In a median follow\u2010up of 21.4\u00a0months after SVR, 39 patients developed LRC including 28 with hepatocellular carcinoma (HCC), with the 30\u2010month cumulative incidence of LRC and HCC being 7.7% and 5.1%, respectively. Predictions of occurrence of LRC and HCC were 0.820 and 0.774 for LS, and 0.775 and 0.737 for Fib\u20104, with optimal cutoffs of LS and Fib\u20104 being 14.5 kPa and 2.9 for LRC prediction. In multivariate analysis, LS was associated with the occurrence of LRC (hazard ratio: 3.97, 95% confidence interval [1.866, 8.446], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) after adjustment for Fib\u20104 and diabetes. A risk\u2010score system combining LS, Fib\u20104, and diabetes was developed for LRC risk assessment. Patients were stratified into low\u2010 (score 0\u20131), intermediate\u2010 (score 2\u20133), and high\u2010risk (score 4) groups with LRC cumulative incidences of 1.7%, 14.9%, and 36.4%, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). For patients with CHC after DAA, the risk scoring system based on LS, Fib\u20104, and diabetes was useful to assess the risk of LRC development during follow\u2010up; accordingly, it would be advantageous for clinicians to set up more personalized and cost\u2010effective strategies of surveillance.<\/jats:p>","DOI":"10.1002\/kjm2.12465","type":"journal-article","created":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T05:22:01Z","timestamp":1634966521000},"page":"268-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Liver stiffness\u2010based score at sustained virologic response predicts liver\u2010related complications after eradication of hepatitis C virus"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0185-1846","authenticated-orcid":false,"given":"Yuan\u2010Hung","family":"Kuo","sequence":"first","affiliation":[{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwong\u2010Ming","family":"Kee","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Hung","family":"Hung","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5493-4752","authenticated-orcid":false,"given":"Sheng\u2010Nan","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Hui","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung 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