{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:24Z","timestamp":1786978164641,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571870"],"award-info":[{"award-number":["81571870"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cognitive dysfunction is a common postoperative neurological complication in patients undergoing valve replacement surgery. This study aimed to compare the effects of sevoflurane versus propofol\u2010based total intravenous anesthesia on the incidence of cognitive dysfunction following valve replacement surgery. This multicenter, randomized, controlled double\u2010blinded study was conducted in three teaching hospitals in China. Patients receiving on\u2010pump valve replacement surgery were enrolled. Stratified block randomization was used to randomly assign patients 1:1 to receive sevoflurane (1.0\u20131.5 MAC) or propofol (2.0\u20133.0\u00a0mg\/kg\/h) for anesthesia maintenance. The primary outcome was the incidence of cognitive dysfunction assessed by four cognitive tests before, as well as 7\u201314\u2009days after surgery. Patients were randomly assigned to receive sevoflurane anesthesia (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0144) or propofol\u2010based total intravenous anesthesia (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0145). The incidence of postoperative cognitive dysfunction in the sevoflurane anesthesia group (31.9%) was significantly lower than that in the total intravenous anesthesia group (43.4%; relative risk 0.61, 95% confidence interval [CI]: 0.38\u20130.97,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.044). There was no difference in the incidence of delirium between patients receiving sevoflurane and total intravenous anesthesia (27.8% [35\/144] vs. 25.9% [35\/145], 1.10, 95% CI: 0.64 to 1.90,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.736). There was a significant difference in the Katz Index on day 3 after surgery (3 [0.9) vs. 3 (1.0], 0.095, 95% CI: 0.05 to 0.43,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.012). No difference was observed in other outcomes between the two groups. For patients undergoing on\u2010pump valve replacement surgery, sevoflurane anesthesia had a smaller effect on cognitive function and independence in daily life activities compared with propofol anesthesia.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.12618","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T07:32:11Z","timestamp":1668065531000},"page":"166-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cognitive function and delirium following sevoflurane or propofol anesthesia for valve replacement surgery: A multicenter randomized controlled trial"],"prefix":"10.1002","volume":"39","author":[{"given":"Guang\u2010You","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Second Affiliated Hospital of Army Military Medical University  Chongqing 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