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The multipass transmembrane protein cleft lip and palate transmembrane protein 1 (Clptm1) controls the forward trafficking of GABA<jats:sub>A<\/jats:sub>R, thus decaying miniature inhibitory postsynaptic current (mIPSC) of inhibitory synapses. In this study, using a pentylenetetrazol (PTZ)\u2010induced epilepsy rat model, we found that Clptm1 regulates epileptic seizures by modulating GABA<jats:sub>A<\/jats:sub>R\u2010mediated inhibitory synaptic transmission. First, we showed that Clptm1 expression was elevated in the PTZ\u2010induced epileptic rats. Subsequently, we found that downregulation of Clptm1 expression protected against PTZ\u2010induced seizures, which was attributed to an increase in the number of GABA<jats:sub>A<\/jats:sub>R\u03b32s in the plasma membrane and the amplitude of mIPSC. Taken together, our findings identify a new anti\u2010seizure target that provides a theoretical basis for the development of novel strategies for the prevention and treatment of epilepsy.<\/jats:p>","DOI":"10.1002\/kjm2.12629","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T09:39:15Z","timestamp":1671097155000},"page":"61-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clptm1, a new target in suppressing epileptic seizure by regulating <scp>GABA<sub>A<\/sub>R<\/scp>\u2010mediated inhibitory synaptic transmission in a <scp>PTZ<\/scp>\u2010induced epilepsy model"],"prefix":"10.1002","volume":"39","author":[{"given":"Xiao\u2010Lin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, The First People's Hospital of Yunnan Province The Affiliated Hospital of Kunming University of Science and Technology  Kunming Yunnan 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