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However, reports with comparisons between both groups are limited in Taiwan. We retrospectively enrolled all cutaneous lymphomas and evaluated their clinicopathologic features. There were 221 cases of lymphoma: 182 (82.3%) primary and 39 (17.7%) secondary. Mycosis fungoides was the most common primary T\u2010cell lymphoma, 92 (41.7%) cases, followed by CD30\u2010positive T\u2010cell lymphoproliferative disorders including lymphomatoid papulosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a033, 14.9%) and cutaneous anaplastic large cell lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a012, 5.4%). The most frequent primary B\u2010cell lymphomas were marginal zone lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, 3.6%) and diffuse large B\u2010cell lymphoma (DLBCL), leg type (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, 3.6%). DLBCL including variants was the most common secondary lymphoma involving skin. Most primary lymphomas presented at low\u2010stage (T\u2010cell, 86%; B\u2010cell, 75%), whereas the majority of secondary lymphomas presented at high\u2010stage (T\u2010cell, 94%; B\u2010cell, 100%). Patients with secondary lymphomas had an older mean age, more frequent B symptoms, lower serum albumin and hemoglobin, and a higher frequency of atypical lymphocytes in blood than those with primary lymphomas. In primary lymphomas, older age, lymphoma types, decreased lymphocyte counts and atypical lymphocytes in blood were poorer prognostic factors. In secondary lymphoma patients, lymphoma types, high serum lactate dehydrogenase and low hemoglobin levels predicted poorer survival. We found that the distribution of primary cutaneous lymphomas in Taiwan mirrors that of other Asian countries but shows some differences as compared with Western countries. Primary cutaneous lymphomas have a better prognosis than secondary lymphomas. Histologic classification of lymphomas highly correlated with disease presentation and prognosis.<\/jats:p>","DOI":"10.1002\/kjm2.12659","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T10:33:40Z","timestamp":1676543620000},"page":"522-532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Distribution and clinical features of lymphomas involving skin in Taiwan"],"prefix":"10.1002","volume":"39","author":[{"given":"Cheng\u2010Lin","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pathology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Institute of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u2010Wei","family":"Chang","sequence":"additional","affiliation":[{"name":"Clinical Informatics and Medical Statistics Research Center Chang Gung University Taoyuan Taiwan"},{"name":"Department of Laboratory Medicine Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia Yu\u2010Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsai\u2010Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Chin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Chia\u2010Yi Christian Hospital Chiayi Taiwan"},{"name":"Department of Cosmetic Science Chia Nan University of Pharmacy and Science Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Bao","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Institute of Basic Medical Sciences, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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