{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:08:57Z","timestamp":1791299337624,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, optical coherence tomography (OCT) biomarkers for specific retinal diseases have been found to be associated with treatment outcome and disease recurrence. The main purposes of this study were to identify OCT biomarkers for myopic choroidal neovascularization (mCNV) treated with intravitreal injection of anti\u2010vascular endothelial growth factor (anti\u2010VEGF). OCT features in 43 eyes of 39 patients with mCNV treated with anti\u2010VEGF with at least 1\u2009year of follow\u2010up were retrospectively analyzed. Eyes with subretinal hyperreflective material (SHM) in baseline spectral\u2010domain OCT (SD\u2010OCT) had significantly more visual improvement than eyes without SHM at month 6 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007) and had a trend of more visual improvement than eyes without SHM (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.058) at month 12. Eyes with subretinal fluid (SRF) at baseline had significantly more central retinal thickness (CRT) decrease than patients without SRF at month 6 and 12 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.012 and 0.006 respectively). In univariate regression analysis, dome\u2010shaped macula (DSM), SRF in baseline OCT image and fuzzy border of mCNV when entering pro re nata (PRN) injection protocol tended to have higher risk of disease recurrence in 1\u2009year (odds ratio: 14.86 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), 3.75 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.049) and 22.92 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) respectively). However, they were not significant in multivariate regression analysis. OCT biomarkers at baseline could provide prognostic information for mCNV management.<\/jats:p>","DOI":"10.1002\/kjm2.12669","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T08:43:50Z","timestamp":1678783430000},"page":"637-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Optical coherence tomography biomarkers for myopic choroidal neovascularization treated with anti\u2010vascular endothelial growth factor"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-6018","authenticated-orcid":false,"given":"Daniel Yu","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shwu\u2010Jiuan","family":"Sheu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"School of Medicine Kaohsiung Medical University  Kaohsiung 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