{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:22:16Z","timestamp":1792858936169,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160908"],"award-info":[{"award-number":["82160908"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The interleukin\u201023 (IL\u201023)\/IL\u201017 immune axis has been linked to the pathology of psoriasis, but how this axis contributes to skin inflammation in this disease remains unclear. We measured inflammatory cytokines associated with the IL\u201023\/IL\u201017 immune axis in the serum of patients with psoriasis using enzyme\u2010linked immunosorbent assays. Psoriasis was induced in male C57BL\/6J mice using imiquimod (IMQ) cream, and animals received intraperitoneal injections of recombinant mouse anti\u2010IL\u201023A or anti\u2010IL\u201017A antibodies for 7\u2009days. The potential effects of the IL\u201023\/IL\u201017 immune axis on skin inflammation were assessed based on pathology scoring, hematoxylin\u2013eosin staining of skin samples, and quantitation of inflammatory cytokines. Western blotting was used to evaluate levels of the following factors in skin: ACT1, TRAF6, TAK1, NF\u2010\u03baB, and pNF\u2010\u03baB. The serum of psoriasis patients showed elevated levels of several cytokines involved in the IL\u201023\/IL\u201017 immune axis: IL\u20102, IL\u20104, IL\u20108, IL\u201012, IL\u201017, IL\u201022, IL\u201023, and interferon\u2010\u03b3. Levels of IL\u201023p19 and IL\u201017 were increased in serum and skin of IMQ\u2010treated mice, while ACT1, TRAF6, TAK1, NF\u2010\u03baB, and pNF\u2010\u03baB were upregulated in the skin. A large proportion of NF\u2010\u03baB p65 localized in nucleus of involucrin\n                    <jats:sup>+<\/jats:sup>\n                    cells in the epidermis and in F4\/80\n                    <jats:sup>+<\/jats:sup>\n                    cells of the dermis of psoriatic lesional skin. Treating these animals with anti\u2010IL\u201023 or anti\u2010IL\u201017 antibodies improved pathological score and immune imbalance, mitigated skin inflammation and downregulated ACT1, TRAF6, TAK1, NF\u2010\u03baB, and pNF\u2010\u03baB in skin. Our results suggest that skin inflammation mediated by the IL\u201023\/IL\u201017 immune axis in psoriasis involves activation of the ACT1\/TRAF6\/TAK1\/NF\u2010\u03baB pathway in keratinocytes and macrophage.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.12683","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T08:49:14Z","timestamp":1682498954000},"page":"789-800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["<scp>IL<\/scp>\n                    \u201023\/\n                    <scp>IL<\/scp>\n                    \u201017 immune axis mediates the imiquimod\u2010induced psoriatic inflammation by activating\n                    <scp>ACT1<\/scp>\n                    \/\n                    <scp>TRAF6<\/scp>\n                    \/\n                    <scp>TAK1<\/scp>\n                    \/\n                    <scp>NF\u2010\u03baB<\/scp>\n                    pathway in macrophages and keratinocytes"],"prefix":"10.1002","volume":"39","author":[{"given":"Wen\u2010Cheng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology First Clinical Medical College, Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5362-6988","authenticated-orcid":false,"given":"Chang\u2010Hui","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Clinical Medical College, Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Clinical Medical College, Guizhou University of Traditional Chinese Medicine  Guiyang 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