{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:40:10Z","timestamp":1785516010258,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This retrospective observational study aims to investigate the patient\u2010controlled intravenous analgesia (PCIA) of dexmedetomidine (DEX) with nalbuphine (NAL) versus sufentanil (SUF) for post\u2010cesarean delivery management. A total of 300 women were evaluated who underwent cesarean section surgery with combined spinal\u2010epidural anesthesia. After surgery, all patients were connected to a patient\u2010controlled analgesia pump. The PCIA protocol was programmed with 0.11\u2009\u03bcg\/kg\/h DEX in combination with 0.03\u2009\u03bcg\/kg\/h SUF in Group I (<jats:italic>n<\/jats:italic>\u2009=\u2009150) or 0.11\u2009\u03bcg\/kg\/h DEX in combination with 0.03\u2009mg\/kg\/h NAL in Group II (<jats:italic>n<\/jats:italic>\u2009=\u2009150). There was no significant difference in incision pain and sedation level between the two groups within 48\u2009h after the surgery assessed by visual analog scale (VAS) and Ramsay sedation scale, respectively. However, at 2, 6, 12, and 24\u2009h after surgery, visceral pain at rest and at mobilization was alleviated in the Group II as compared with the Group I with lower VAS scores. Moreover, fewer adverse reactions were found in the Group II when compared with Group I, including postpartum respiratory depression, nausea\/vomiting, urinary retention, and cardiovascular events. Overall, there was an increased patient satisfaction in the Group II as compared with the Group I. Based on the results of this study, it seems that adding NAL to PCIA with DEX, as compared to SUF with DEX, have an effect on reducing the intensity of visceral pain after cesarean section with less adverse reactions and higher patient satisfaction.<\/jats:p>","DOI":"10.1002\/kjm2.12689","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T08:40:21Z","timestamp":1682325621000},"page":"740-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Patient\u2010controlled intravenous administration of dexmedetomidine with nalbuphine versus sufentanil for post cesarean delivery analgesia: A retrospective observational study"],"prefix":"10.1002","volume":"39","author":[{"given":"Wei\u2010Wei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Xuzhou Maternal and Children Health Care Hospital  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Xuzhou Mine Hospital  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Xuzhou Maternal and Children Health Care Hospital  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010Ming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Xuzhou Maternal and Children Health Care Hospital  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Nan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Xuzhou Maternal and Children Health Care Hospital  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-2306","authenticated-orcid":false,"given":"Zhi\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Xuzhou Maternal and Children Health Care Hospital  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2020-0305"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13526"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31828866b3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S242545"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-016-0543-2"},{"key":"e_1_2_6_7_1","volume-title":"Patient controlled analgesia","author":"Pastino A","year":"2022"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666180-00005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0419-5"},{"issue":"3","key":"e_1_2_6_10_1","first-page":"1778","article-title":"Effects of dexmedetomidine hydrochloride on hemodynamics, postoperative analgesia and cognition in cesarean section","volume":"16","author":"Kong D","year":"2018","journal-title":"Exp Ther Med"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172702"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.87265"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2020.1766025"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S363743"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2344733"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8994946"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2020.03.003"},{"issue":"237","key":"e_1_2_6_18_1","first-page":"473","article-title":"Postpartum hemorrhage in pregnancy beyond 40\u2009weeks of gestation in a tertiary care hospital: a descriptive cross\u2010sectional study","volume":"59","author":"Bastakoti Gaire R","year":"2021","journal-title":"JNMA J Nepal Med Assoc"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12334"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.5603\/GP.a2018.0072"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2022.110892"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/ija.IJA_773_18"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9054538"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.937963"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cursur.2004.10.002"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182783b72"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-017-0507-7"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-021-01472-4"},{"issue":"2","key":"e_1_2_6_29_1","first-page":"198","article-title":"Safety and effectiveness of adding fentanyl or sufentanil to spinal anesthesia: systematic review and meta\u2010analysis of randomized controlled trials","volume":"73","author":"Fonseca NM","year":"2021","journal-title":"Braz J Anesthesiol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12873-022-00592-x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.908212"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13022"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-021-00334-0"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.574493"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S184782"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2019.545"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-022-00425-6"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-021-00275-8"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c00820"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-22-1026"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S380292"}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/kjm2.12689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T17:16:12Z","timestamp":1692292572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/kjm2.12689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,24]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/kjm2.12689"],"URL":"https:\/\/doi.org\/10.1002\/kjm2.12689","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,24]]},"assertion":[{"value":"2023-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}