{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:50:41Z","timestamp":1776721841273,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lenvatinib has been approved as one of the first\u2010line treatments for advanced hepatocellular carcinoma (HCC) due to its high treatment efficacy being non\u2010inferior to sorafenib. Previous studies have shown well\u2010controlled viremia contributes to the prognosis of HCC patients receiving first\u2010line sorafenib; hence, we postulated this association might also exist in HCC patients with lenvatinib treatment. From April 2018 to December 2021, 201 unresectable HCC patients with first\u2010line lenvatinib treatment in our institute were assessed. High\u2010effect nucleoside analogues were administered for hepatitis B virus (HBV) control, while direct\u2010acting antivirals were used for hepatitis C virus (HCV) elimination. Based on our previous study, well\u2010controlled viremia was defined as patients who had undetectable viremia, or who had been receiving antivirals at least 6 months before lenvatinib. This study enrolled 129 patients, including 85 patients with HBV\u2010related HCC (HBV\u2010HCC) and 44 patients with HCV\u2010related HCC (HCV\u2010HCC), respectively. Progression\u2010free survival (PFS) and overall survival (OS) rates between the two groups were not different. Before administration of lenvatinib, 57.1% of the HBV\u2010HCC patients and 88.4% of the HCV\u2010HCC patients had well\u2010controlled viremia, and their PFS (8.8 vs. 3.1\u2009months, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and OS (30.2 vs. 12.8\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.041) were better than those who had uncontrolled viremia; moreover, well\u2010controlled viremia reduced tumor progression in multivariate analysis (Hazard ratio: 0.41, 95% confidence interval: 0.25\u20130.68, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) after adjusting for albumin\u2013bilirubin grade and concurrent treatment. HBV or HCV infection was not associated with tumor progression of HCC patients receiving lenvatinib, but viremia, controlled or not, was.<\/jats:p>","DOI":"10.1002\/kjm2.12757","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:48:53Z","timestamp":1697460533000},"page":"1233-1242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Well\u2010controlled viremia reduces the progression of hepatocellular carcinoma in chronic viral hepatitis patients treated with lenvatinib"],"prefix":"10.1002","volume":"39","author":[{"given":"Ya\u2010Wen","family":"Hsiao","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fai\u2010Meng","family":"Sou","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology, Department of 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