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Existing evidence suggests a potential positive association between CHB and the development of insulin resistance and T2DM. The presence of T2DM in CHB patients is associated with an increased risk of liver fibrosis, cirrhosis, decompensation, and hepatocellular carcinoma (HCC) occurrence. Moreover, it elevates the risk of non\u2010liver cancers and all\u2010cause mortality in this population. T2DM also serves as the key element in metabolic dysfunction\u2010associated steatotic liver disease, which is prevalent in the CHB population. Although specific guidelines for managing T2DM in CHB patients have not been proposed, some studies indicated that intensive glycemic control may benefit the prognosis of these patients. Additionally, specific antidiabetic agents, such as metformin and thiazolidinediones, promise to reduce HCC risk. However, unresolved questions, including the optimal glycemic control target and the selection of antidiabetic agents for CHB patients, remain and thus warrant further investigations through well\u2010designed prospective trials. Implementing a standardized protocol encompassing regular monitoring, risk stratification, and early intervention using a multidisciplinary framework may improve the outcomes of diabetic CHB patients.<\/jats:p>","DOI":"10.1002\/kjm2.12762","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T08:26:29Z","timestamp":1695284789000},"page":"6-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The interplay between chronic hepatitis B and diabetes mellitus: A narrative and concise review"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2507-9627","authenticated-orcid":false,"given":"Shang\u2010Chin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Bei\u2010Hu Branch  Taipei Taiwan"},{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine 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