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Rats' behavior, neurological deficits, brain injury, inflammation, and apoptosis in the brain tissue were evaluated. The inflammatory response and apoptosis of PC12 cells induced by oxygen glucose deprivation\/reperfusion (OGD\/R) were detected. SAA\u2010mediated changes in miR\u2010212\u20103p, SOX7, and Wnt\/\u03b2\u2010catenin pathway were determined, and the targeting relationship between miR\u2010212\u20103p and SOX7 was clarified. SAA alleviated the neurological deficits and brain injury of MCAO rats and inhibited the inflammatory response and apoptosis of OGD\/R\u2010conditioned PC\u201012 cells. SAA upregulated miR\u2010212\u20103p, Wnt3a, and \u03b2\u2010catenin, whereas inhibited SOX7 levels. Silencing miR\u2010212\u20103p counteracted the protective effect of SAA in the context of CIRI. SOX7 was a target protein of miR\u2010212\u20103p. Silencing SOX7 based on SAA and miR\u2010212\u20103p knockdown suppressed OGD\/R\u2010induced inflammation and apoptosis and increased Wnt3a and \u03b2\u2010catenin levels in PC12 cells. SAA can improve the brain and nervous system injury caused by cerebral ischemia\u2013reperfusion by upregulating miR\u2010212\u20103p, thereby inhibiting SOX7 and activating the Wnt\/\u03b2catenin signaling pathway.<\/jats:p>","DOI":"10.1002\/kjm2.12779","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:13:46Z","timestamp":1700612026000},"page":"1222-1232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Salvianolic acid <scp>A<\/scp> improves nerve regeneration and repairs nerve defects in rats with brain injury by downregulating <scp>miR<\/scp>\u2010212\u20103p\u2010mediated <scp>SOX7<\/scp>"],"prefix":"10.1002","volume":"39","author":[{"given":"Shuai","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong)  Nantong City Jiangsu Province 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