{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:13:45Z","timestamp":1787872425256,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["18411970200"],"award-info":[{"award-number":["18411970200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intestinal ischemia\/reperfusion (I\/R) injury is a life\u2010threatening condition with no effective treatment currently available. Curcumin (CCM), a polyphenol compound in Curcuma Longa, reportedly has positive effects against intestinal I\/R injury. However, the mechanism underlying the protective effect of CCM against intestinal I\/R injury has not been fully clarified. To determine whether the protective effect of CCM was mediated by epigenetic effects on Wnt\/\u03b2\u2010catenin signaling, the effect of CCM was examined in vivo and in vitro. An intestinal I\/R model was established in Sprague\u2013Dawley (SD) rats with superior mesenteric artery occlusion, and Caco\u20102 cells were subjected to hypoxia\/reoxygenation (H\/R) for in vivo simulation of I\/R. The results showed that CCM significantly reduced inflammatory, cell apoptosis, and oxidative stress induced by I\/R insult in vivo and in vitro. Western blot analysis showed that CCM preconditioning reduced the protein levels of \u03b2\u2010catenin, p\u2010GSK3\u03b2, and cyclin\u2010D1 and increased the protein level of GSK3\u03b2 compared with the I\/R group. Overexpressing \u03b2\u2010catenin aggravated H\/R injury, and knocking down \u03b2\u2010catenin relieved H\/R injury by improving intestinal permeability and reducing the cell apoptosis. Moreover, Naked cuticle homolog 2(NKD2) mRNA and protein levels were upregulated in the CCM\u2010pretreated group. 5\u2010aza\u20102\u2032\u2010deoxycytidine (5\u2010AZA) treatment improved intestinal epithelial barrier impairment induced by H\/R. Besides, the protein levels of total \u03b2\u2010catenin, phosphor\u2010\u03b2\u2010catenin and cyclin\u2010D1 were reduced after overexpressing NKD2 in Caco\u20102 cells following H\/R insult. In conclusion, Our study suggests that CCM could attenuate intestinal I\/R injury in vitro and in vivo by suppressing the Wnt\/\u03b2\u2010catenin signaling pathway via inhibition of NKD2 methylation.<\/jats:p>","DOI":"10.1002\/kjm2.12782","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T01:15:12Z","timestamp":1701134112000},"page":"175-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Curcumin suppresses the Wnt\/\u03b2\u2010catenin signaling pathway by inhibiting <scp>NKD2<\/scp> methylation to ameliorate intestinal ischemia\/reperfusion injury"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0127-9584","authenticated-orcid":false,"given":"Jia\u2010Xi","family":"Zhu","sequence":"first","affiliation":[{"name":"Center of Emergency and Critical Medicine Jinshan Hospital of Fudan University  Shanghai China"},{"name":"Research Center for 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