{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:42:56Z","timestamp":1791499376336,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bladder cancer (BC) poses high morbidity and mortality, with urinary exosomal microRNA (miR)\u201021 showing potential value in its diagnosis and prognosis, and we probed its specific role. We prospectively selected 116 BC patients and 116 healthy volunteers as the BC and control groups, respectively. BC urinary exosomal miR\u2010146a\u20105p, miR\u201093\u20105p, miR\u2010663b, miR\u201021, and miR\u20104454 relative expression levels were assessed. The correlations between clinical indexes and urinary exosomal miR\u201021, prognostic value of miR\u201021, and diagnostic value of the five candidate miRNAs, urine cytology, and miRNA joint diagnostic panel for BC and urinary exosomal miR\u201021, miR\u20104454, and urine cytology for Ta\u2010T1 and T2\u2010T4 stage BC were analyzed. Urinary exosomal miR\u2010146a\u20105p, miR\u201093\u20105p, miR\u2010663b, miR\u201021, and miR\u20104454 were highly expressed in BC patients. miR\u2010146a\u20105p, miR\u201093\u20105p, miR\u2010663b, miR\u201021, miR\u20104454, miRNA combined diagnostic panel, and urine cytology had certain diagnostic value for BC, with miR\u201021, miR\u20104454, and miRNA co\u2010diagnostic panel showing the highest diagnostic value. Collectively, urinary exosomal miR\u201021 was closely related to Tumor\u2010Node\u2010Metastasis staging and grading in BC patients. Urinary exosomal miR\u201021 had high diagnostic value for BC and Ta\u2010T1 and T2\u2010T4 stage BC, and had high predictive value for BC poor prognosis, providing an effective indicator for the occurrence, development, and prognostic assessment of BC.<\/jats:p>","DOI":"10.1002\/kjm2.12845","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T14:54:40Z","timestamp":1716821680000},"page":"660-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The value of urinary exosomal <scp>microRNA<\/scp>\u201021 in the early diagnosis and prognosis of bladder cancer"],"prefix":"10.1002","volume":"40","author":[{"given":"Fu\u2010Kan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Urology Guangdong Medical University  Zhanjiang 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