{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:20:05Z","timestamp":1767925205963,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112\u20102314\u2010B\u2010303\u2010007\u2010MY3"],"award-info":[{"award-number":["NSTC 112\u20102314\u2010B\u2010303\u2010007\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005925","name":"Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["TCMF\u2010A 107\u201002\u201003"],"award-info":[{"award-number":["TCMF\u2010A 107\u201002\u201003"]}],"id":[{"id":"10.13039\/501100005925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Striated esophageal muscle contraction (SEC) is important for pharyngeal swallowing and deglutition augmentation against aspiration. Its clinical relevance is unclear in patients with ineffective esophageal motility (IEM). In this study, we aimed to characterize and compare SEC in consecutive patients with and without IEM. All eligible patients were evaluated for SEC, primary and secondary peristalsis using high\u2010resolution manometry (HRM) with one mid\u2010esophageal injection port. Primary peristalsis was assessed with 10 5\u2010mL liquid swallows and multiple rapid swallows (MRS), while secondary peristalsis was performed with rapid air injections of 20\u2009mL. All peristatic parameters of HRM were measured, and SEC and its contractile integral (SECI) were evaluated. One hundred and forty patients (59.3% women, mean age 46.1\u2009\u00b1\u200913.1\u2009years) were included. There was no difference in SECI between patients with and without IEM (<jats:italic>p<\/jats:italic>\u2009=\u20090.91). SECI was also similar between patients with and without secondary peristalsis for IEM (<jats:italic>p<\/jats:italic>\u2009=\u20090.63) or normal motility (<jats:italic>p<\/jats:italic>\u2009=\u20090.80). No difference in SECI was seen between patients with and without MRS for IEM (<jats:italic>p<\/jats:italic>\u2009=\u20090.55) or normal motility (<jats:italic>p<\/jats:italic>\u2009=\u20090.88). SECI was significantly higher in male patients than female patients in IEM patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.01). SECI significantly correlated with age in patients with normal motility (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.31, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). Aging may have a negative impact on SEC in patients with normal motility, while gender difference in SECI occurs in IEM patients. Neither secondary peristalsis nor MRS influences SECI.<\/jats:p>","DOI":"10.1002\/kjm2.12884","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T12:43:24Z","timestamp":1722516204000},"page":"942-946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relevance of ineffective esophageal motility to striated esophageal muscle contraction: Studies with high\u2010resolution manometry"],"prefix":"10.1002","volume":"40","author":[{"given":"Jui\u2010Sheng","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Yi","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Wun","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hsun","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tso\u2010Tsai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9084-8210","authenticated-orcid":false,"given":"Chien\u2010Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"},{"name":"Institute of Medical Sciences Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198402023100503"},{"key":"e_1_2_6_3_1","first-page":"561","volume-title":"Gastrointestinal and liver Disease: pathophysiology, diagnosis, management","author":"Clouse RE","year":"2002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(22)60840-0"},{"issue":"4","key":"e_1_2_6_5_1","first-page":"G525","article-title":"Analyses of normal and 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