{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:16Z","timestamp":1786978156320,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC112\u20102314\u2010B\u2010037\u2010103"],"award-info":[{"award-number":["NSTC112\u20102314\u2010B\u2010037\u2010103"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Different human leukocyte antigen (HLA) genotypes have been known to be associated with the risk of development of Sj\u00f6gren's syndrome in different populations, but this association has never been reported in Taiwan. We enrolled 1044 subjects (673 patients, 371 controls) and tested their HLA\u2010DR genotypes. We found an increased risk of Sj\u00f6gren's syndrome in patients carrying HLA\u2010DR8. DR1 and DR14 were associated with increased risk of eye involvement (uveitis, scleritis or optic neuritis), while DR15 was associated with increased risk of interstitial lung disease. DR8 was associated with increased risk of formation of multiple antibodies: anti\u2010Ro, rheumatoid factor and antinuclear antibodies (ANA) reaching titer 1:80 or above. DR9 was associated with decreased risk of formation of anti\u2010La antibodies and increased risk of formation of antithyroglobulin antibodies. DR10 was associated with risk of formation of anticyclic citrullinated peptide (anti\u2010CCP) antibodies, and DR11 was associated with increased risk of formation of anti\u2010La antibodies. Oral ulcer was found to be negatively associated with anti\u2010Ro antibodies and with anti\u2010ENA antibodies. Skin lesions were associated with ANA antibody titer elevation to 1:80 or above. Malignancies of any kind were associated with the presence of cryoglobulin. Females were more likely to be diagnosed at a younger age than males. There was no statistically significant relationship between HLA\u2010DR genotype and age at disease diagnosis. In patients with Sj\u00f6gren's syndrome in Taiwan, the presence of HLA\u2010DR8 appeared to be a risk factor. In addition, we found several associations between HLA\u2010DR genotype, clinical presentation, and autoantibody status among them.<\/jats:p>","DOI":"10.1002\/kjm2.12885","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T08:03:54Z","timestamp":1723104234000},"page":"934-941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>HLA<\/scp>\n                    \u2010\n                    <scp>DR<\/scp>\n                    genotypes in patients with primary Sj\u00f6gren's syndrome in Taiwan"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-6420","authenticated-orcid":false,"given":"Chang\u2010Yi","family":"Yen","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Institute of Medical Informatics, College of Electrical Engineering and Computer Science National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Internal Medicine Kaohsiung Municipal Ta\u2010Tung Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin\u2010Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung 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