{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:33:00Z","timestamp":1789144380103,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the impact of LNP023 on the AMPK\/mTOR signaling pathway in lupus nephritis (LN) and its effects on autophagy and oxidative stress. A mouse model of LN was established, and renal injury was confirmed by assessing various LN markers, including antinuclear antibody, ds\u2010DNA, anti\u2010Sm antibody, and others. Mice were treated with LNP023, the AMPK activator AICAR, or the AMPK inhibitor dorsomorphin. Renal injury and fibrosis were evaluated using HE and Masson staining. Expression levels of AMPK, mTOR, LC3, Beclin1, and p62 were assessed by immunohistochemistry and Western blot. Oxidative stress and inflammatory markers were measured by polymerase chain reaction and enzyme\u2010linked immunosorbent assay. LN mice exhibited low AMPK\/p\u2010AMPK and high mTOR\/p\u2010mTOR levels, alongside significant renal injury, fibrosis, reduced autophagy, and elevated oxidative stress. LNP023 treatment improved these parameters, with enhanced effects when combined with AICAR. Conversely, dorsomorphin reversed LNP023's therapeutic benefits. The complement factor B inhibitor LNP023 promotes kidney health in LN mice by mediating the AMPK\/mTOR pathway, promoting autophagy, and attenuating oxidative stress.<\/jats:p>","DOI":"10.1002\/kjm2.12894","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T10:39:09Z","timestamp":1728729549000},"page":"996-1005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Complement factor <scp>B<\/scp> inhibitor <scp>LNP023<\/scp> mediates the effect and mechanism of <scp>AMPK<\/scp>\/<scp>mTOR<\/scp> on autophagy and oxidative stress in lupus nephritis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4504-2007","authenticated-orcid":false,"given":"Xi\u2010Mei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nephrology The Second Affiliated Hospital of University of South China  Hengyang 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