{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:21:04Z","timestamp":1776370864059,"version":"3.51.2"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113\u20102314\u2010B\u2010037\u2010028"],"award-info":[{"award-number":["NSTC 113\u20102314\u2010B\u2010037\u2010028"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigates predictors of unsatisfactory outcomes in female overactive bladder (OAB) patients treated with oral monotherapy by analyzing skin sympathetic nerve activity (SKNA) using a novel \u201cneuECG\u201d method. The study included 55 newly diagnosed female patients with idiopathic OAB, autonomic function was evaluated using neuECG before treatment initiation, and validated OAB questionnaires and urodynamic studies were administered. Initial monotherapy was administered for the first 4\u2009weeks, with non\u2010responders defined as patients not achieving satisfactory symptom relief and requiring further treatment. Responders (<jats:italic>n<\/jats:italic>\u2009=\u200932) and non\u2010responders (<jats:italic>n<\/jats:italic>\u2009=\u200923) had no significant differences in baseline characteristics or urodynamic parameters; however, non\u2010responders exhibited significantly higher baseline average SKNA (aSKNA) (1.36\u2009\u00b1\u20090.49 vs. 0.97\u2009\u00b1\u20090.29\u2009\u03bcV, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), higher recovery aSKNA (1.28\u2009\u00b1\u20090.46 vs. 0.97\u2009\u00b1\u20090.35\u2009\u03bcV, <jats:italic>p<\/jats:italic>\u2009=\u20090.007), and a lower stress\/baseline ratio of aSKNA (1.05\u2009\u00b1\u20090.42 vs. 1.26\u2009\u00b1\u20090.26, <jats:italic>p<\/jats:italic>\u2009=\u20090.029). Baseline aSKNA had the highest predictive value for monotherapy refractoriness in OAB (AUROC\u2009=\u20090.759, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), with an optimal cut\u2010off point of &gt;1.032\u2009\u03bcV. These findings suggest that elevated pre\u2010treatment aSKNA can predict resistance to oral monotherapy in OAB, warranting close monitoring and proactive treatment strategies for patients with high aSKNA.<\/jats:p>","DOI":"10.1002\/kjm2.12899","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T10:14:51Z","timestamp":1728468891000},"page":"1020-1028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Higher skin sympathetic nerve activity as a potential predictor of overactive bladder in females refractory to oral monotherapy"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-136X","authenticated-orcid":false,"given":"Yu\u2010Chen","family":"Chen","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Urology, Kaohsiung 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