{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:30:51Z","timestamp":1767137451228,"version":"build-2238731810"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST109\u20102314\u2010B\u2010037\u2010030"],"award-info":[{"award-number":["MOST109\u20102314\u2010B\u2010037\u2010030"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006578","name":"Chi Mei Medical Center","doi-asserted-by":"publisher","award":["CMFHR10754"],"award-info":[{"award-number":["CMFHR10754"]}],"id":[{"id":"10.13039\/501100006578","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Patients with chronic migraine (CM) often exhibit structural and functional alterations in pain\u2010matrix regions, but it remains unclear how preventive treatment affects these changes. Therefore, this study aimed to investigate the structural and functional changes in pain\u2010matrix regions in CM patients after 6\u2010month treatment. A total of 24 patients with CM and 15 healthy controls were recruited for this study. Patients were divided into responder group (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20099) and non\u2010responder group (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200915). After completing the Migraine Disability Assessment (MIDAS) questionnaire, all patients underwent whole\u2010brain high\u2010resolution T1\u2010weighted images, diffusion\u2010weighted imaging, and resting\u2010state functional magnetic resonance imaging at baseline and 6\u2010month follow\u2010up. Whole brain gray matter volume and white matter diffusion indices were analyzed using voxel\u2010based analysis. Structural and functional connectivity analyses were performed to understand brain changes in patients after 6\u2010month preventive treatment. The responder group exhibited significantly higher MIDAS scores than the non\u2010responder group at baseline, but no significant difference between the two groups at follow\u2010up. No significant interval change was noted in gray matter volume, white matter diffusion indices, and structural connectivity in CM patients after 6\u2010month treatment. Nonetheless, the functional connectivity was significantly increased between occipital, temporal lobes and cerebellum, and was significantly decreased between parietal and temporal lobes after 6\u2010month preventive treatment. We concluded that resting\u2010state functional connectivity was suitable for investigating the preventive treatment effect on CM patients.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.12903","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T06:35:47Z","timestamp":1729665347000},"page":"1077-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preventive treatment effects on brain structures and functions in patients with chronic migraine: A multimodel magnetic resonance imaging study"],"prefix":"10.1002","volume":"40","author":[{"given":"Tai\u2010Yuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiology Chi Mei Medical Center  Tainan Taiwan"},{"name":"Graduate Institute of Medical Sciences Chang Jung Christian University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Chung","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Radiology Chi Mei Medical Center  Tainan Taiwan"},{"name":"Department of Health and Nutrition Chia Nan University of Pharmacy and Science  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poh\u2010Shiow","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Neurology Chi Mei Medical Center  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Te\u2010Chang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Chi Mei Medical Center  Tainan Taiwan"},{"name":"Department of Medical Sciences Industry Chang Jung Christian University  Tainan Taiwan"},{"name":"Department of Biomedical Imaging and Radiological Sciences National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Ju","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Radiology Chi Mei Medical Center  Tainan Taiwan"},{"name":"Graduate Institute of Medical Sciences Chang Jung Christian University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Chi Mei Medical Center  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u2010Chi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Chi Mei Medical Center  Tainan Taiwan"},{"name":"Institute of Healthcare Information Management National Chung Cheng University  Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8488-2693","authenticated-orcid":false,"given":"Ming\u2010Chung","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Radiological Sciences Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Medical Research Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Center for Big Data Research Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kao\u2010Chang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology and Holistic Care Chi Mei Medical Center  Tainan 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