{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:17:06Z","timestamp":1767136626890,"version":"build-2238731810"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3H0402"],"award-info":[{"award-number":["CMRPG3H0402"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3H0403"],"award-info":[{"award-number":["CMRPG3H0403"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3H0942"],"award-info":[{"award-number":["CMRPG3H0942"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3H0943"],"award-info":[{"award-number":["CMRPG3H0943"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 109\u20102314\u2010B\u2010182 \u2010049 \u2010MY3"],"award-info":[{"award-number":["MOST 109\u20102314\u2010B\u2010182 \u2010049 \u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The impacts of insulin degludec U100 (Deg\u2010100) and insulin glargine U300 (Gla\u2010300) on glycemic variability (GV) in patients with type 1 diabetes, as well as the impact of major nutrient components on GV in these patients, remain unclear. This was an observational, cross\u2010sectional, retrospective study. Type 1 diabetes mellitus patients treated with either Deg\u2010100 or Gla\u2010300 as basal insulin were enrolled. After the participants underwent continuous glucose monitoring, GV indices and major nutrient components were analyzed. Forty patients with type 1 diabetes were enrolled, and 20 participants used Deg\u2010100, and 20 used Gla\u2010300. There was no significant difference in major nutrient components between the two groups. Better GV indices of standard deviation, coefficient of variation, mean amplitude of glycemic excursion, AUC\n                    <jats:sub>\n                      <jats:italic>n<\/jats:italic>\n                    <\/jats:sub>\n                    ,\n                    <jats:italic>M<\/jats:italic>\n                    \u2010value, CONGA1, CONGA2, and CONGA4 were noted in the Gla\u2010300 group versus Deg\u2010100 group. Compared with patients who received once\u2010daily injection in the morning (QD), Deg\u2010100 administration once daily at bedtime (HS) yielded a higher low blood glucose index during both day and nocturnal periods, indicating a higher risk of hypoglycemic events. By contrast, there were significantly lower levels of CONGA1, CONGA2, and CONGA4 during insulin Gla\u2010300 QD administration than during HS administration, indicating a lower GV of a short interval. In this real\u2010world study involving type 1 diabetes patients, Gla\u2010300 appears to offer more stable glucose variability than Deg\u2010100. Administering once\u2010daily injections could lower the risk of hypoglycemia in the Deg\u2010100 group and minimize GV in the Gla\u2010300 group compared to bedtime injections.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.12909","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T06:54:39Z","timestamp":1732604079000},"page":"1086-1094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of insulin glargine\n                    <scp>U300<\/scp>\n                    versus insulin degludec\n                    <scp>U100<\/scp>\n                    on glycemic variability, hypoglycemia, and diet evaluated by continuous glucose monitoring in type 1 diabetes: a retrospective cross\u2010sectional study"],"prefix":"10.1002","volume":"40","author":[{"given":"Pin\u2010Lun","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Medical Education Chang Gung Memorial Hospital  Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Chang Gung Memorial Hospital  Linkou Taiwan"},{"name":"Department of Chinese Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Medical Nutrition Therapy Chang Gung Memorial Hospital  Linkou Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-6140","authenticated-orcid":false,"given":"Yu\u2010Yao","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Chang Gung Memorial Hospital  Linkou Taiwan"},{"name":"Department of Chinese Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Chang Gung Memorial Hospital  Linkou Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9297-6320","authenticated-orcid":false,"given":"Yi\u2010Hsuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Chang Gung Memorial Hospital  Linkou Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.14.1707"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2015.30.2.167"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2017.0388"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2016.40.6.423"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31818b38d2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0706"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0684"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7115"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7117"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1033"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12938"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0991"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0990"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12438"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-022-01410-x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14161"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-019-0870-x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2016.40.4.326"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296815599177"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2010.0247"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2008.0132"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-020-00529-z"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0559"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/db23-1803-PUB"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2017.10.001"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ15-0438"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-017-0269-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14898"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1285147"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124380"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsaa046"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-019-00707-x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-019-02043-z"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2006.10.005"}],"updated-by":[{"DOI":"10.1002\/kjm2.70090","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000}}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/kjm2.12909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T04:41:46Z","timestamp":1733373706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/kjm2.12909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,26]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/kjm2.12909"],"URL":"https:\/\/doi.org\/10.1002\/kjm2.12909","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,26]]},"assertion":[{"value":"2024-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}