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In alignment with the Taiwanese government's objective to eliminate hepatitis C by 2025, this study aimed to provide real\u2010world evidence on the use of this regimen in treatment\u2010na\u00efve patients with chronic kidney disease (CKD) by using data from the Taiwan Association for the Study of the Liver HCV Registry (TACR). CKD was defined by an estimated glomerular filtration rate (eGFR) of &lt;60\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> or higher with proteinuria persisting for over 3\u2009months. Patients were categorized as having early CKD (eGFR \u226545\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>) or pre\u2010end\u2010stage renal disease (pre\u2010ESRD) (eGFR &lt;45\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>). Among 1072 patients who received at least one dose of the regimen, 1054 had available data for assessing sustained virologic response at 12\u2009weeks posttreatment (SVR12). The overall SVR12 rate was 99.6%, with rates of 99.7% for pre\u2010ESRD patients and 99.6% for early CKD patients. Subgroup analysis showed 100% efficacy for genotype 3 and dyslipidemia, 99.5% for diabetes, 99.4% for cardiovascular disease, 96.9% for a history of cerebral vascular accident, and 95.5% for patients with a history of drug injection or HIV co\u2010infection. Adverse events were reported in 16.8% of patients, with 0.8% experiencing serious events, and only two cases were treatment\u2010related. Renal function significantly improved, with overall eGFR increasing from 39.2 to 41.9\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>. Early CKD patients showed an eGFR rise from 53.5 to 57.1, while pre\u2010ESRD patients improved from 27.1 to 29.2 at SVR12. The study concluded that the 8\u2010week regimen is highly effective, well\u2010tolerated, and associated with significant renal function improvement in treatment\u2010na\u00efve CHC patients with both early CKD and pre\u2010ESRD.<\/jats:p>","DOI":"10.1002\/kjm2.12929","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T07:04:49Z","timestamp":1737356689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010world efficacy and safety of universal 8\u2010week glecaprevir\/pibrentasvir in patients with chronic hepatitis C with early chronic kidney disease or pre\u2010end\u2010stage renal disease: Insights from a nationwide hepatisis <scp>C virus<\/scp> registry in Taiwan"],"prefix":"10.1002","volume":"41","author":[{"given":"Szu\u2010Jen","family":"Wang","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine Kaohsiung Medical University  Kaohsiung 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