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While traditional treatment aims to promptly restore blood flow to the retina, recent research has investigated the potential benefits of anticoagulation therapy for managing this condition. This paper reviews current literature and clinical trials investigating the efficacy and safety of anticoagulant and antiplatelet therapies, such as systemic heparinization and direct oral anticoagulants and aspirin, in treating RAO. The mechanism of action involves preventing thrombus propagation and platelet aggregation to promote microvascular circulation, potentially mitigating ischemic damage and improving visual outcomes. However, controversies exist regarding the optimal timing, duration, and selection of antithrombotic agents due to the risk of hemorrhagic complications. Further large\u2010scale prospective studies are warranted to establish evidence\u2010based guidelines for incorporating antithrombotic into the standard management of RAO. This paper underscores the evolving landscape of antithrombotic therapy as a promising adjunctive treatment strategy in the management of retinal artery occlusion.<\/jats:p>","DOI":"10.1002\/kjm2.12938","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T12:52:21Z","timestamp":1737031941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antithrombotic use in retinal artery occlusion: A narrative review"],"prefix":"10.1002","volume":"41","author":[{"given":"Wan\u2010Yu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Education Chang Gung Memorial Hospital, Linkou Main Branch  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Hsin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Chang Gung Memorial Hospital, Linkou Main Branch  Taoyuan 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